A new approach to evaluate mechanistic relationships among genotoxic phenomena: validation

Obviously, insight into the mechanistic basis of toxicological can be concluded that the two phenomena are related mechanistically to one action is needed to assess the risks posed by chemicals. One another. (Similarly, if the observed prevalence is significantly lower than the of the approaches to the elucidation of this problem is to expected one, this suggests that the two phenomena are antagonistic to one evaluate the congruence between the induction of different another, e.g. they could compete for a specific receptor.) toxicological phenomena. Thus, if a group of chemicals induces In implementing such an approach, it quickly becomes obvious that there is a dearth of experimental data on the same chemicals across a variety of a significantly higher than expected incidence of both chromo- toxicological end points. Hence, the significance of the observed joint somal aberrations and developmental anomalies, then one prevalences cannot be ascertained. The current approach was devised to might conclude that the two phenomena are related, possibly overcome this shortcoming. It is based upon the availability of characterized