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Differential Recognition of Terminal Extracellular Plasmodium falciparum VAR2CSA Domains by Sera from Multigravid, Malaria-Exposed Malian Women
- Source :
- The American Journal of Tropical Medicine and Hygiene, Travassos, M A, Coulibaly, D, Bailey, J A, Niangaly, A, Adams, M, Nyunt, M M, Ouattara, A, Lyke, K E, Laurens, M B, Pablo, J, Jasinskas, A, Nakajima, R, Berry, A A, Takala-Harrison, S, Kone, A K, Kouriba, B, Rowe, J A, Doumbo, O K, Thera, M A, Laufer, M K, Felgner, P L & Plowe, C V 2015, ' Differential recognition of terminal extracellular Plasmodium falciparum VAR2CSA domains by sera from multigravid, malaria-exposed Malian women ', American Journal of Tropical Medicine and Hygiene, vol. 92, no. 6, pp. 1190-1194 . https://doi.org/10.4269/ajtmh.14-0524
- Publication Year :
- 2015
- Publisher :
- The American Society of Tropical Medicine and Hygiene, 2015.
-
Abstract
- The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediates parasite sequestration in small capillaries through tissue-specific cytoadherence. The best characterized of these proteins is VAR2CSA, which is expressed on the surface of infected erythrocytes that bind to chondroitin sulfate in the placental matrix. Antibodies to VAR2CSA prevent placental cytoadherence and protect against placental malaria. The size and complexity of the VAR2CSA protein pose challenges for vaccine development, but smaller constitutive domains may be suitable for subunit vaccine development. A protein microarray was printed to include five overlapping fragments of the 3D7 VAR2CSA extracellular region. Malian women with a history of at least one pregnancy had antibody recognition of four of these fragments and had stronger reactivity against the two distal fragments than did nulliparous women, children, and men from Mali, suggesting that the C-terminal extracellular VAR2CSA domains are a potential focus of protective immunity. With carefully chosen sera from longitudinal studies of pregnant women, this approach has the potential to identify seroreactive VAR2CSA domains associated with protective immunity against pregnancy-associated malaria.
- Subjects :
- Adult
Male
Protein subunit
030231 tropical medicine
Plasmodium falciparum
Protein Array Analysis
Antigens, Protozoan
Gravidity
Biology
Cross Reactions
Mali
03 medical and health sciences
Young Adult
0302 clinical medicine
Blood serum
Antigen
Immunity
Pregnancy
Virology
parasitic diseases
medicine
Extracellular
Humans
Malaria, Falciparum
Child
030304 developmental biology
0303 health sciences
Infant
Articles
medicine.disease
biology.organism_classification
3. Good health
Infectious Diseases
Child, Preschool
Pregnancy Complications, Parasitic
embryonic structures
biology.protein
Parasitology
Female
Antibody
Malaria
Subjects
Details
- Language :
- English
- ISSN :
- 14761645 and 00029637
- Volume :
- 92
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The American Journal of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi.dedup.....78524eb8d91aeffa9451ec84bd4e165b
- Full Text :
- https://doi.org/10.4269/ajtmh.14-0524