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Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020), Nature Communications
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- The strategies concerning modification of the complex immune pathological inflammatory environment during acute spinal cord injury remain oversimplified and superficial. Inspired by the acidic microenvironment at acute injury sites, a functional pH-responsive immunoregulation-assisted neural regeneration strategy was constructed. With the capability of directly responding to the acidic microenvironment at focal areas followed by triggered release of the IL-4 plasmid-loaded liposomes within a few hours to suppress the release of inflammatory cytokines and promote neural differentiation of mesenchymal stem cells in vitro, the microenvironment-responsive immunoregulatory electrospun fibers were implanted into acute spinal cord injury rats. Together with sustained release of nerve growth factor (NGF) achieved by microsol core-shell structure, the immunological fiber scaffolds were revealed to bring significantly shifted immune cells subtype to down-regulate the acute inflammation response, reduce scar tissue formation, promote angiogenesis as well as neural differentiation at the injury site, and enhance functional recovery in vivo. Overall, this strategy provided a delivery system through microenvironment-responsive immunological regulation effect so as to break through the current dilemma from the contradiction between immune response and nerve regeneration, providing an alternative for the treatment of acute spinal cord injury.<br />Inflammatory responses determine the pathological course of spinal cord injury. Here, the authors report on pH responsive fibers for triggered release of IL-4 plasmid liposomes and sustained release of nerve growth factor to regulate the immune response and promote nerve regeneration to enhance functional recovery.
- Subjects :
- Angiogenesis
Science
General Physics and Astronomy
Inflammation
Spinal cord injury
General Biochemistry, Genetics and Molecular Biology
Article
Proinflammatory cytokine
Biomaterials
Drug Delivery Systems
Immune system
Nerve Growth Factor
Animals
Humans
Medicine
lcsh:Science
Spinal Cord Injuries
Multidisciplinary
Tissue Scaffolds
business.industry
Regeneration (biology)
Mesenchymal stem cell
Cell Differentiation
Mesenchymal Stem Cells
Recovery of Function
General Chemistry
Hydrogen-Ion Concentration
medicine.disease
Nerve Regeneration
Rats
Cell biology
Disease Models, Animal
Drug Liberation
Nerve growth factor
Cellular Microenvironment
Spinal Cord
Delayed-Action Preparations
Liposomes
Drug delivery
lcsh:Q
Female
Interleukin-4
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....785ba8f324728ff2cbc1ea1929e38b05