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Spinal cord fMRI with MB‐SWIFT for assessing epidural spinal cord stimulation in rats
- Source :
- Magnetic Resonance in Medicine
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Purpose: Electrical epidural spinal cord stimulation (SCS) is used as a treatment for chronic pain as well as to partially restore motor function after a spinal cord injury. Monitoring the spinal cord activity during SCS with fMRI could provide important and objective measures of integrative responses to treatment. Unfortunately, spinal cord fMRI is severely challenged by motion and susceptibility artifacts induced by the implanted electrode and bones. This pilot study introduces multi-band sweep imaging with Fourier transformation (MB-SWIFT) technique for spinal cord fMRI during SCS in rats. Given the close to zero acquisition delay and high bandwidth in 3 dimensions, MB-SWIFT is demonstrated to be highly tolerant to motion and susceptibility-induced artifacts and thus holds promise for fMRI during SCS. Methods: MB-SWIFT with 0.78 × 0.78 × 1.50 mm3 spatial resolution and 3-s temporal resolution was used at 9.4 Tesla in rats undergoing epidural SCS at different frequencies. Its performance was compared with spin echo EPI. The origin of the functional contrast was also explored using suppression bands. Results: MB-SWIFT was tolerant to electrode-induced artifacts and respiratory motion, leading to substantially higher fMRI sensitivity than spin echo fMRI. Clear stimulation frequency-dependent responses to SCS were detected in the rat spinal cord close to the stimulation site. The origin of MB-SWIFT fMRI signals was consistent with dominant inflow effects. Conclusion: fMRI of the rat spinal cord during SCS can be consistently achieved with MB-SWIFT, thus providing a valuable experimental framework for assessing the effects of SCS on the central nervous system. publishedVersion
- Subjects :
- Central nervous system
Pilot Projects
Stimulation
Spinal cord stimulation
epidural stimulation
030218 nuclear medicine & medical imaging
zero echo time
03 medical and health sciences
0302 clinical medicine
Animals
Medicine
Radiology, Nuclear Medicine and imaging
Spinal cord injury
Research Articles—Preclinical and Clinical Imaging
Spinal Cord Stimulation
Full Paper
MB‐SWIFT
business.industry
fMRI
Respiratory motion
Chronic pain
3126 Surgery, anesthesiology, intensive care, radiology
Spinal cord
medicine.disease
Magnetic Resonance Imaging
Rats
medicine.anatomical_structure
Spinal Cord
nervous system
High bandwidth
Artifacts
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15222594 and 07403194
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance in Medicine
- Accession number :
- edsair.doi.dedup.....787a5bb5f5c4c1f75210233f8182aa8e