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Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus
- Source :
- Endocrine. 55:165-172
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16-18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35-0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus.
- Subjects :
- Adult
China
medicine.medical_specialty
Bilirubin
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Lower risk
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Asian People
Health Transition
Pregnancy
Diabetes mellitus
Internal medicine
medicine
Humans
Prospective Studies
Hyperbilirubinemia
Glucose tolerance test
medicine.diagnostic_test
Obstetrics
business.industry
Incidence
Type 2 Diabetes Mellitus
Confounding Factors, Epidemiologic
Glucose Tolerance Test
medicine.disease
Pregnancy Complications
Gestational diabetes
Diabetes, Gestational
chemistry
Pregnancy Trimester, Second
Relative risk
Female
business
Biomarkers
Maternal Serum Screening Tests
Follow-Up Studies
Subjects
Details
- ISSN :
- 15590100 and 1355008X
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....78825ee2ffd1242e9a734eb92a5efdda