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Glomerular and Tubular Function in the Diabetic Kidney
- Source :
- Advances in Chronic Kidney Disease. 21:297-303
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Diabetes mellitus with its attendant complications is a significant cause of morbidity and mortality with diabetic nephropathy being the leading cause of end stage renal disease in the Western world. Characteristic structural and functional changes in the kidney early in the course of diabetes have been shown to have enduring effects on the progression of disease. A better understanding of the mechanisms underlying these changes is imperative to the development of new therapeutic strategies. Renal hypertrophy and hyperfiltration along with proximal tubular hyperreabsorption are among the distinctive features of early diabetic nephropathy. Additionally, there are particular alterations in the sensitivity of the glomerular and tubular function to dietary salt intake in early diabetes. Herein, we focus on these early physiologic changes and discuss some of the primary and secondary mechanisms discovered in recent years which lead to these alterations in kidney function.
- Subjects :
- medicine.medical_specialty
Kidney
business.industry
Renal Hypertrophy
Kidney Glomerulus
Physiology
Renal function
Disease
medicine.disease
End stage renal disease
Diabetic nephropathy
Kidney Tubules
medicine.anatomical_structure
Endocrinology
Nephrology
Internal medicine
Renal physiology
Diabetes mellitus
medicine
Humans
Diabetic Nephropathies
Sodium Chloride, Dietary
business
Subjects
Details
- ISSN :
- 15485595
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Advances in Chronic Kidney Disease
- Accession number :
- edsair.doi.dedup.....788f398905e40f443cdf8bab44e8db3c
- Full Text :
- https://doi.org/10.1053/j.ackd.2014.03.006