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Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications

Authors :
Danielle Santana-Coelho
Grace A. Porter
Mustafa N. Mithaiwala
Jason C. O'Connor
Source :
Cells, Vol 10, Iss 1548, p 1548 (2021), Cells
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Diseases of the central nervous system (CNS) remain a significant health, social and economic problem around the globe. The development of therapeutic strategies for CNS conditions has suffered due to a poor understanding of the underlying pathologies that manifest them. Understanding common etiological origins at the cellular and molecular level is essential to enhance the development of efficacious and targeted treatment options. Over the years, neuroinflammation has been posited as a common link between multiple neurological, neurodegenerative and neuropsychiatric disorders. Processes that precipitate neuroinflammatory conditions including genetics, infections, physical injury and psychosocial factors, like stress and trauma, closely link dysregulation in kynurenine pathway (KP) of tryptophan metabolism as a possible pathophysiological factor that ‘fuel the fire’ in CNS diseases. In this study, we aim to review emerging evidence that provide mechanistic insights between different CNS disorders, neuroinflammation and the KP. We provide a thorough overview of the different branches of the KP pertinent to CNS disease pathology that have therapeutic implications for the development of selected and efficacious treatment strategies.

Details

Language :
English
ISSN :
20734409
Volume :
10
Issue :
1548
Database :
OpenAIRE
Journal :
Cells
Accession number :
edsair.doi.dedup.....78a3d5bd7de0a0e613bc90174a98393a