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Delayed diagnosis of congenital thrombotic thrombocytopenic purpura in a patient with recurrent strokes
- Source :
- Journal of Thrombosis and Thrombolysis
- Publication Year :
- 2022
- Publisher :
- Springer US, 2022.
-
Abstract
- Congenital thrombotic thrombocytopenic purpura (cTTP) is caused by ADAMTS13 mutations and associated with high risk of microvascular thrombosis. A 58 year old female had an ischemic stroke during hormonal fertility, and a TIA a year after. She suffered another stroke 18 years later while on warfarin. Four months after she developed severe thrombocytopenia, mild anemia, and increased LDH. Blood film showed schistocytes. She was hospitalized with presumptive TTP. ADAMTS 13 activity was undetectable without inhibitor. She developed another stroke and received plasma exchange. A homozygote ADAMTS 13 mutation was identified. Despite plasma, the ADAMTS13 activity remained
- Subjects :
- Delayed Diagnosis
Purpura, Thrombotic Thrombocytopenic
ADAMTS13 Protein
Anemia
Thrombosis
Hematology
Middle Aged
Article
Congenital thrombotic thrombocytopenia purpura
Stroke
Cryptogenic recurrent strokes
Recurrence
hemic and lymphatic diseases
Humans
Female
Cardiology and Cardiovascular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 1573742X and 09295305
- Database :
- OpenAIRE
- Journal :
- Journal of Thrombosis and Thrombolysis
- Accession number :
- edsair.doi.dedup.....78aada1260ee38e9897b4b5a6cc0083c