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HPV-related Sinonasal Carcinoma
- Source :
- American Journal of Surgical Pathology. 44:305-315
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- The prevalence and prognostic value of human papillomavirus (HPV) infection and epidermal growth factor receptor (EGFR) alteration in sinonasal squamous cell carcinoma (SNSCC) are not known. The reliability of p16 overexpression as a surrogate for HPV infection in SNSCC is also unclear. We investigated the prognostic and diagnostic significances of HPV infection, EGFR alteration, and p16 expression in SNSCC. We analyzed high-risk HPV infection by HPV-RNA in situ hybridization and EGFR gene copy number gain (CNG) by chromogenic in situ hybridization and by determining the protein expressions of p16, Rb, and EGFR by immunohistochemistry in 101 SNSCC cases. HPV infection (n=9, 8.9%) and p16 overexpression (n=15, 14.9%) were associated with better overall survival (P=0.0042 and 0.005, respectively). The HPV cases were located predominantly at the nasal cavity with nonkeratinizing histology and partial loss of Rb. Notably, 40% (6/15) of p16 SNSCCs were HPV. Two of these cases showed complete loss of Rb expression by immunohistochemistry, suggesting a reason for the above discrepancy. EGFR CNG, detected in 30.5% of the SNSCCs, was correlated with EGFR protein overexpression (P=0.0001). HPV infection and EGFR CNG were mutually exclusive. The HPV/EGFR CNG group had significantly better overall survival than the HPV/EGFR CNG and HPV/EGFR CNG groups (P=0.0471 and 0.0343, respectively). Our results suggest that HPV infection is a favorable prognostic marker in SNSCC, but p16 is not a perfect surrogate marker; the Rb expression pattern may improve the diagnostic accuracy. The molecular subclassification of SNSCCs based on HPV infection and EGFR copy number status might provide important information for therapeutic strategies.
- Subjects :
- Adult
Male
0301 basic medicine
DNA Copy Number Variations
Chromogenic in situ hybridization
In situ hybridization
Retinoblastoma Protein
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Biomarkers, Tumor
Carcinoma
Humans
Medicine
Copy-number variation
Epidermal growth factor receptor
EGFR Protein Overexpression
Cyclin-Dependent Kinase Inhibitor p16
Aged
Retrospective Studies
Aged, 80 and over
biology
business.industry
Genes, p16
Papillomavirus Infections
HPV infection
Reproducibility of Results
virus diseases
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
ErbB Receptors
Gene Expression Regulation, Neoplastic
030104 developmental biology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Cancer research
biology.protein
Female
Surgery
Anatomy
business
Paranasal Sinus Neoplasms
Follow-Up Studies
Subjects
Details
- ISSN :
- 01475185
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- American Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....78bbf68413fbaf7389ce487b623c22a4