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The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis
- Source :
- Climacteric : the journal of the International Menopause Society. 20(5)
- Publication Year :
- 2017
-
Abstract
- The platelet-to-lymphocyte ratio (PLR) is a predictive clinical biomarker for different cancers. However, the results of several studies investigating the association between the PLR and the prognosis of ovarian cancer have been inconclusive. Therefore, there is a need to conduct a meta-analysis to estimate the prognostic value of the PLR in ovarian cancer.We searched the EMBASE, Medline, PubMed, and Web of Science databases to identify clinical studies that had evaluated the association between the PLR and ovarian cancer prognosis. Outcomes evaluated included overall survival (OS) and progression-free survival (PFS). We also analyzed PLR differences between malignant ovarian masses and the controls.Twelve relevant studies that comprised 2340 patients were selected for the meta-analysis. The results revealed that elevated PLR was significantly associated with poor OS (hazard ratio (HR) 1.63, 95% confidence interval (CI) 1.05-2.56, p 0.01) and PFS (HR 1.61, 95% CI 1.03-2.51, p 0.01). The PLRs in malignant cases were higher than in controls (mean difference = 63.57, 95% CI 39.47-87.66, p 0.00001).An elevated PLR is associated with poor prognosis in patients with ovarian cancer. The PLR could be employed as a prognostic marker in patients with ovarian cancer.
- Subjects :
- 0301 basic medicine
Oncology
Adult
medicine.medical_specialty
Lymphocyte
MEDLINE
macromolecular substances
Clinical biomarker
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Text mining
Risk Factors
Internal medicine
medicine
Humans
Platelet
Lymphocyte Count
Aged
Proportional Hazards Models
Gynecology
Aged, 80 and over
Ovarian Neoplasms
business.industry
Platelet Count
Obstetrics and Gynecology
General Medicine
Middle Aged
medicine.disease
Prognosis
body regions
Survival Rate
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Meta-analysis
Female
Ovarian cancer
business
Subjects
Details
- ISSN :
- 14730804
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Climacteric : the journal of the International Menopause Society
- Accession number :
- edsair.doi.dedup.....78e1d4dca1ba755fa4d36dbde8ec63d5