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MicroRNA29
- Source :
- Circulation. 127:1466-1475
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- Background— Congestive heart failure (CHF) causes atrial fibrotic remodeling, a substrate for atrial fibrillation (AF) maintenance. MicroRNA29 (miR29) targets extracellular matrix proteins. In the present study, we examined miR29b changes in patients with AF and/or CHF and in a CHF-related AF animal model and assessed its potential role in controlling atrial fibrous tissue production. Methods and Results— Control dogs were compared with dogs subjected to ventricular tachypacing for 24 hours, 1 week, or 2 weeks to induce CHF. Atrial miR29b expression decreased within 24 hours in both whole atrial tissue and atrial fibroblasts (−87% and −92% versus control, respectively; p p p p p p p p p p p Conclusions— MiR29 likely plays a role in atrial fibrotic remodeling and may have value as a biomarker and/or therapeutic target.
- Subjects :
- Male
Pacemaker, Artificial
medicine.medical_specialty
Medizin
Extracellular matrix
Mice
Dogs
Physiology (medical)
Internal medicine
Atrial Fibrillation
medicine
Animals
Humans
Sinus rhythm
Heart Atria
Aged
Heart Failure
Gene knockdown
Messenger RNA
Ventricular Remodeling
business.industry
Myocardium
Atrial fibrillation
Middle Aged
medicine.disease
Fibrosis
Mice, Inbred C57BL
Disease Models, Animal
MicroRNAs
Endocrinology
Heart failure
Cardiology
Biomarker (medicine)
Female
Cardiology and Cardiovascular Medicine
business
Fibrillin
Biomarkers
Subjects
Details
- ISSN :
- 15244539 and 00097322
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....78e6cafe5247660118095df3dcbbd69b