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Correction to: OTOGL, a gelforming mucin protein, is nonessential for male germ cell development and spermatogenesis in mice
- Source :
- Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-3 (2021), Reproductive Biology and Endocrinology : RB&E
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Otogelin-like protein (encoded by Otogl) was highly structural similar to the gelforming mucin proteins. Although human OTOG mutations have been linked to deafness, the biological function of OTOGL in male germ cell development remains enigmatic. In screening 336 patients with non-obstructive azoospermia (NOA), OTOGL displays the high mutant ratio (13.99 %). Then, we examined the expression of OTOGL in developing mouse testes. Otogl mRNA and protein are continually expressed in postnatal developing testes from postnatal day 0 (P0) testes to P21 testes exhibiting a decreased trend with the age growth. We thus generated a global Otogl knockout mouse (KO) model using the CRISPR/Cas9 technology; however, Otogl KO mice displayed normal development and fertility. Further histological analysis of Otogl knockout mouse testes revealed that all types of spermatogenic cells are present in Otogl KO seminiferous tubules. Together, our study suggested that OTOGL is nonessential for male germ cell development and spermatogenesis.
- Subjects :
- Male
medicine.medical_specialty
QH471-489
Mutation, Missense
Reproductive medicine
Biology
Andrology
Mice
Endocrinology
Testis
medicine
Animals
Humans
Spermatogenesis
Azoospermia
Mice, Knockout
Reproduction
Mucin
Mucins
Correction
Membrane Proteins
Obstetrics and Gynecology
Gynecology and obstetrics
Germ Cells
medicine.anatomical_structure
Reproductive Medicine
RG1-991
Germ cell
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 14777827
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Reproductive Biology and Endocrinology
- Accession number :
- edsair.doi.dedup.....78fccd71e3a5ca9b10480921bf49bf8c