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Modified FOLFIRINOX versus CisGem first-line chemotherapy for locally advanced non resectable or metastatic biliary tract cancer (AMEBICA)-PRODIGE 38: Study protocol for a randomized controlled multicenter phase II/III study
- Source :
- Digestive and Liver Disease, Digestive and Liver Disease, WB Saunders, 2019, 51 (2), pp.318-320. ⟨10.1016/j.dld.2018.11.018⟩, Digestive and Liver Disease, 2019, 51 (2), pp.318-320. ⟨10.1016/j.dld.2018.11.018⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- IF 3.287 (2017); International audience; IntroductionCombination of cisplatine and Gemcitabine (CisGem) is the reference 1st line Chemotherapy in patients with advanced biliary cancer. FOLFIRINOX demonstrated an overall survival superiority when compared to gemcitabine in 1st line for patients with metastatic pancreatic adenocarcinoma. Because of similarities between pancreatic and biliary cancers, we proposed a randomized trial comparing mFOLFIRINOX and CisGEm.AimPRODIGE38-AMEBICA is a phase II/III trial evaluating efficacy of modifed FOLFIRINOX (D1 bolus removed) or CisGEm on patients with locally advanced non resectable or metastatic biliary tract cancer.Patients and methodsMain inclusion criteria are histologically or cytologically proven biliary tract tumor (intra or extra hepatic or hilar or gallbladder carcinoma), measurable disease (metastases and/or primary tumor), Bilirubin
- Subjects :
- Male
medicine.medical_specialty
FOLFIRINOX
medicine.medical_treatment
Modified folfirinox
Leucovorin
Antineoplastic Agents
[SDV.CAN]Life Sciences [q-bio]/Cancer
Advanced biliary cancer
Irinotecan
Deoxycytidine
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Carcinoma
Humans
Medicine
Neoplasm Invasiveness
Neoplasm Staging
Chemotherapy
Hepatology
business.industry
Gallbladder
Metastatic Pancreatic Adenocarcinoma
medicine.disease
Gemcitabine
Primary tumor
3. Good health
Oxaliplatin
medicine.anatomical_structure
Bile Duct Neoplasms
Biliary tract
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Fluorouracil
France
Cisplatin
Drug Monitoring
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 15908658
- Database :
- OpenAIRE
- Journal :
- Digestive and Liver Disease, Digestive and Liver Disease, WB Saunders, 2019, 51 (2), pp.318-320. ⟨10.1016/j.dld.2018.11.018⟩, Digestive and Liver Disease, 2019, 51 (2), pp.318-320. ⟨10.1016/j.dld.2018.11.018⟩
- Accession number :
- edsair.doi.dedup.....79150c9d3269b4aaab55e9151f187ff6