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Modification of the rat uterine response to oestrogen and tamoxifen by thromboxane antagonists
- Source :
- Scopus-Elsevier
- Publication Year :
- 1991
-
Abstract
- 1. The thromboxane receptor antagonists EP092, AH23848 and BM 13.505 were used to investigate the role of thromboxane in the uterotrophic response to oestradiol and tamoxifen. 2. The parameters examined were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights and the concentrations of cytosolic and nuclear oestrogen receptors. 3. Only EP092 potentiated the hyperaemic response to oestrogen but all three thromboxane antagonists inhibited oestradiol-stimulated uterine growth. This inhibition was accompanied by a decrease in nuclear oestrogen receptor concentration. 4. The uterotrophic response to tamoxifen was unaffected by the thromboxane antagonists. 5. The mechanism by which the thromboxane antagonists may be exerting their growth inhibitory effect is discussed, although, whether this effect can be attributed to blockade of thromboxane receptors or to some other mechanism is not clear from this study.
- Subjects :
- medicine.medical_specialty
Thromboxane
medicine.drug_class
Thromboxane receptor
Rats, Sprague-Dawley
Internal medicine
Prostaglandins, Synthetic
medicine
Animals
Receptor
skin and connective tissue diseases
Phenylacetates
Pharmacology
Sulfonamides
biology
Estradiol
Biphenyl Compounds
Uterus
Thromboxanes
Organ Size
Antiestrogen
Rats
Biphenyl compound
Tamoxifen
Endocrinology
Receptors, Estrogen
Estrogen
Regional Blood Flow
biology.protein
Female
Thromboxane-A synthase
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....794dc39a3ad851b263010ef9a2e599ad