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A variant of acute promyelocytic leukemia with t(4;17)(q12;q21) showed two different clinical symptoms
- Source :
- Hematology Reports, Vol 11, Iss 3 (2019), Hematology Reports
- Publication Year :
- 2019
- Publisher :
- PAGEPress Publications, 2019.
-
Abstract
- A 63-year-old man was diagnosed with a rare variant of acute promyelocytic leukemia (APL) with t(4;17)(q12; q21) that showed atypical morphological features and two different clinical symptoms. He was started on standard induction chemotherapy for acute myeloid leukemia, which decreased myeloblast numbers; however, APL-like blasts remained. He then received a salvage therapy that added all-trans retinoic acid (ATRA). After ATRA commenced, APL-like blasts disappeared and cytogenetic analysis became normal. However, myeloblasts subsequently increased, and he became resistant. In summary, this patient exhibited two different clinical courses of acute myeloid leukemia and APL.
- Subjects :
- Acute promyelocytic leukemia
Retinoic acid
Salvage therapy
Case Report
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
immune system diseases
Myeloblast
hemic and lymphatic diseases
Medicine
PML-RARA
neoplasms
t(4
17)(q12
q21)
business.industry
lcsh:RC633-647.5
Myeloid leukemia
Induction chemotherapy
Hematology
lcsh:Diseases of the blood and blood-forming organs
acute promyelocytic leukemia
medicine.disease
all-trans retinoic acid
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Cancer research
business
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 20388330 and 20388322
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Hematology Reports
- Accession number :
- edsair.doi.dedup.....79613388d22e34cac886233388231dfb