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Association of AHSG gene polymorphisms with serum Fetuin-A levels in individuals with cardiovascular calcification in west of Iran
- Source :
- Molecular Biology Reports. 47:1809-1820
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Fetuin-A (AHSG) is a multifunctional secretory protein and acts as an ectopic valve and artery calcification inhibitor. We assessed the correlation between serum levels of Fetuin-A and both exon 6 (248 C/T) and exon 7 (256 C/G) mutations in patients with coronary artery calcification (CAC), mitral annular calcification (MAC), and aortic valve calcification (AVC). 184 patients and 184 healthy individuals as control group were included. The genetic variants of rs4917 and rs4918 for the AHSG gene were determined by PCR-RFLP and T-ARMS PCR techniques. Fetuin-A levels, fasting blood sugar (FBS), urea, creatinine, calcium phosphorus, and lipid profile were measured. Fetuin-A levels were remarkedly lower in individuals with AVC, MAC, and CAC comparing to the control group (p
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Genotype
alpha-2-HS-Glycoprotein
Single-nucleotide polymorphism
Iran
Polymorphism, Single Nucleotide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cardiovascular calcification
Internal medicine
Genetics
Humans
Medicine
Vascular Calcification
Molecular Biology
Genetic Association Studies
Aged
Aged, 80 and over
Creatinine
medicine.diagnostic_test
business.industry
Calcinosis
Aortic Valve Stenosis
General Medicine
Middle Aged
medicine.disease
Coronary Vessels
Coronary arteries
030104 developmental biology
Blood pressure
Endocrinology
medicine.anatomical_structure
chemistry
Aortic Valve
Case-Control Studies
030220 oncology & carcinogenesis
Mitral Valve
Female
Aortic valve calcification
business
Lipid profile
Calcification
Subjects
Details
- ISSN :
- 15734978 and 03014851
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Molecular Biology Reports
- Accession number :
- edsair.doi.dedup.....7971d4b04e9abd647df554bfd30b5f5c
- Full Text :
- https://doi.org/10.1007/s11033-020-05275-z