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White matter disruption in obsessive‐compulsive disorder revealed by meta‐analysis of tract‐based spatial statistics
- Source :
- Depression and Anxiety. 37:620-631
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Background Exploring white matter (WM) microstructural alterations is a momentous step for gaining insights about underlying mechanisms of obsessive-compulsive disorder (OCD) and improving the efficacy of therapies for this condition. Many tract-based spatial statistics (TBSS) studies have revealed abnormalities of fractional anisotropy (FA; an index of WM integrity) in OCD. However, research works have not drawn robust conclusions. Therefore, we integrated the findings of TBSS studies to identify the most consistent FA changes in OCD using meta-analytical approach. Methods Online databases were systematically searched for all TBSS studies comparing FA between patients with OCD and controls. A coordinate-based meta-analysis was performed using anisotropic effect size version of the seed-based d mapping software. Meanwhile, meta-regression was used to explore the potential association of clinical characteristics with regional FA abnormalities. Results Our meta-analysis included 488 OCD patients and 519 controls across 17 datasets. FA reductions were identified in the genu of the corpus callosum and the left orbitofrontal WM in OCD patients relative to controls. Metaregression analyses showed that the FA in the left orbitofrontal WM was negatively and independently correlated with symptom severity and illness duration in patients with OCD. Conclusions The current study provides a quantitative overview of TBSS findings in OCD and demonstrates the most prominent and replicable WM abnormalities in OCD are in the anterior part of the brain including interhemispheric connection and orbitofrontal region. Additionally, our findings suggest that FA reduction in the orbitofrontal WM might be a potential biomarker in predicting disease severity and progression in patients with OCD.
- Subjects :
- Obsessive-Compulsive Disorder
medicine.medical_specialty
Genu of the corpus callosum
Audiology
Tract based spatial statistics
behavioral disciplines and activities
Corpus Callosum
White matter
03 medical and health sciences
0302 clinical medicine
Disease severity
Obsessive compulsive
mental disorders
Fractional anisotropy
medicine
Humans
business.industry
Brain
White Matter
030227 psychiatry
Psychiatry and Mental health
Clinical Psychology
Diffusion Tensor Imaging
medicine.anatomical_structure
Meta-analysis
Anisotropy
business
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- ISSN :
- 15206394 and 10914269
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Depression and Anxiety
- Accession number :
- edsair.doi.dedup.....79762d7308df27cc6be0cf63f77e1d50