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Assisted Breathing with a Diaphragm Pacing System: A Systematic Review
- Source :
- Yonsei Medical Journal
- Publication Year :
- 2020
- Publisher :
- Yonsei University College of Medicine, 2020.
-
Abstract
- Purpose Patients with respiratory failure associated with neurological dysfunction often require mechanical ventilator support, which poses increased economic burden and ventilator-associated complications. A diaphragm pacing system (DPS) is an implanted device that provides respiratory support for such patients. In this systematic review, we reviewed the literature to assess the safety and efficacy of DPS for patients with respiratory failure resulting from amyotrophic lateral sclerosis (ALS) or cervical spinal cord injuries. Materials and methods The following databases were searched from July 10 to July 30, 2018: MEDLINE, EMBASE, Cochran library, KoreaMed, Research Information Sharing Service, Korean studies Information Service System, Korea Institute of Science and Technology Information, and Korean Medical database. The abstracts and full texts of the searched articles were reviewed by two reviewers. Results The search keywords generated 197 articles: two randomized controlled trials, two case-control studies, and one case report involving patients with ALS; one cohort study, one case-control study, and two case reports involving patients with cervical spine injury; and one case report involving patients with both conditions were included. The primary outcome was safety profile (complications and adverse event) and efficacy (overall survival and sleep improvement). Complications and adverse events were more common in patients with ALS and spinal cord injury receiving DPS than in controls. Efficacy outcomes were inconsistent across ALS studies. Conclusion Based on safety and efficacy results, we do not support using DPS to manage respiratory failure in patients with ALS or cervical spine injury.
- Subjects :
- medicine.medical_specialty
Diaphragm
MEDLINE
030204 cardiovascular system & hematology
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Medicine
Humans
Amyotrophic lateral sclerosis
Adverse effect
Spinal cord injury
Spinal Cord Injuries
business.industry
Respiration
Amyotrophic Lateral Sclerosis
General Medicine
Prostheses and Implants
medicine.disease
Respiration, Artificial
spinal cord injury
Diaphragm pacing
Pulmonology & Critical Care Medicine
Treatment Outcome
Respiratory failure
030220 oncology & carcinogenesis
Emergency medicine
Original Article
business
electrical stimulation therapy
Respiratory Insufficiency
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 19762437 and 05135796
- Volume :
- 61
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Yonsei Medical Journal
- Accession number :
- edsair.doi.dedup.....7976612082f0df4b4107596020d0fd25