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An open-label, prospective interventional study of the tolerability and efficacy of 0.4 mg oral tamsulosin oral controlled absorption system in men with lower urinary tract symptoms associated with benign prostatic hyperplasia who are unsatisfied with treatment with 0.2 mg tamsulosin
- Source :
- Clinical Interventions in Aging
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Pei-Shan Yang,1 Chien-Lun Chen,1 Chen-Pang Hou,1 Yu-Hsiang Lin,1 Ke-Hung Tsui1,2 1Department of Urology, 2Prostate Health Laser Center, Chang Gung Memorial Hospital-Linkou, Chang Gung University, College of Medicine, Taipei, Taiwan, Republic of China Purpose: The aim of this study was to investigate the efficacy and tolerability of switching from 0.2mg tamsulosin to 0.4mg tamsulosin oral controlled absorption system (OCAS) over a 12-week period in Taiwanese men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Patients and methods: Taiwanese male patients who were dissatisfied with treatment with 0.2mg tamsulosin were enrolled in this clinical study and switched to 0.4mg tamsulosin OCAS. Efficacy was assessed over a 12-week period by an International Prostate Symptom Score (IPSS) questionnaire and analysis of urinary flow by uroflowmetry. Results: A statistically significant improvement was observed in total IPSS scores from baseline (14.94±7.41, moderate) to 12weeks (7.36±5.77, mild) in 81 patients who were switched from 0.2 to 0.4mg tamsulosin OCAS (P
- Subjects :
- Male
Tamsulosin
α1-adrenergic receptor
medicine.medical_specialty
neoplasms
Prostatic Hyperplasia
030232 urology & nephrology
Urology
Administration, Oral
Urination
outcomes
urologic and male genital diseases
03 medical and health sciences
0302 clinical medicine
Lower Urinary Tract Symptoms
Quality of life
Lower urinary tract symptoms
medicine
Humans
Nocturia
Prospective Studies
030212 general & internal medicine
Adverse effect
Original Research
Aged
Aged, 80 and over
Sulfonamides
prostate
LUTS
business.industry
Drug Tolerance
General Medicine
Middle Aged
medicine.disease
Treatment Outcome
Blood pressure
Tolerability
Patient Satisfaction
Clinical Interventions in Aging
Quality of Life
Urological Agents
International Prostate Symptom Score
Geriatrics and Gerontology
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 11781998
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Clinical Interventions in Aging
- Accession number :
- edsair.doi.dedup.....797715eb703d47c13efbe3cdb26712dc