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Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks
- Source :
- Cells, Cells, Vol 9, Iss 2, p 337 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on glioblastoma, representative of a highly aggressive and deleterious neoplasm in humans. First, we highlight recent advances and emerging concepts for how tumor cells and different recruited normal cells contribute to the sphingosine-1-phosphate enrichment in the cancer microenvironment. Then, we describe and discuss how sphingosine-1-phosphate signaling contributes to favor cancer hallmarks including enhancement of proliferation, stemness, invasion, death resistance, angiogenesis, immune evasion and, possibly, aberrant metabolism. We also discuss the potential of how sphingosine-1-phosphate control mechanisms are coordinated across distinct cancer microenvironments. Further progress in understanding the role of S1P signaling in cancer will depend crucially on increasing knowledge of its participation in the tumor microenvironment.
- Subjects :
- Angiogenesis
Cancer Microenvironment
Review
Biology
chemistry.chemical_compound
Immune system
Sphingosine
Neoplasms
medicine
Tumor Microenvironment
Neoplasm
cancer
Animals
Humans
Sphingosine-1-phosphate
lcsh:QH301-705.5
Tumor microenvironment
glioblastoma
Cancer
Biological Transport
General Medicine
medicine.disease
chemistry
lcsh:Biology (General)
Cancer research
sphingosine-1-phosphate
Neoplastic Stem Cells
cancer hallmarks
Lysophospholipids
Glioblastoma
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 9
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....797db3bc85fcffb8a276a06dac64314e