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Dietary fatty acid oxidation is decreased in non-alcoholic fatty liver disease: A palmitate breath test study
- Source :
- Liver Int
- Publication Year :
- 2019
-
Abstract
- Background & aim Hepatic fat excess in non-alcoholic fatty liver disease (NAFLD) reflects an imbalance between fat accumulation and disposal. Conflicting data exist for the role of fatty acid oxidation (FAO), one of the disposal pathways, and have mostly come from the studies delivering fatty acids (FAs) intravenously. Whether FAO of orally provided FAs is affected in NAFLD is unknown. Methods We performed a breath test study to measure FAO in subjects with NAFLD and healthy controls. Subjects ingested [1-13 C] palmitic acid (PA, 10 mg/kg) in a liquid meal and the rate of 13 CO2 appearance in expired air was measured over 6 hours by a BreathID device (Exalenz) to obtain the cumulative percent dose recovered (CPDR), the total amount of ingested 13 C recovered. CPDR was corrected by the results of a [1-13 C] acetate breath test, performed 1-4 weeks later, to calculate the rate of PA β-oxidation. Results Palmitic acid oxidation was 27% lower in 43 subjects with NAFLD compared to 11 controls (CPDR 9.5 ± 2.4% vs 13.1 ± 3.7%, P = .0001) and this persisted after correcting for acetate (29.3 ± 10.5 vs 36.6 ± 13.9, P = .03). The decrease in FAO was not because of the delayed transit as the time to peak 13 C detection did not differ between groups (4.9 ± 1.2 hours vs 4.7 ± 0.8 hours, P = .7). Rates of PA oxidation were not correlated with obesity, hepatic or adipose insulin resistance, alanine aminotransferase, liver fat content and NAFLD histology. Conclusion Fatty acid oxidation of orally delivered FA is decreased in NAFLD compared to healthy controls, likely reflecting decreased β-oxidation. The use of a breath test offers non-invasive dynamic assessment of FAO.
- Subjects :
- medicine.medical_specialty
Palmitates
Adipose tissue
Article
Palmitic acid
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Non-alcoholic Fatty Liver Disease
Internal medicine
medicine
Humans
Beta oxidation
Breath test
Hepatology
medicine.diagnostic_test
business.industry
Fatty liver
digestive, oral, and skin physiology
Fatty Acids
Histology
medicine.disease
Lipid Metabolism
Obesity
Endocrinology
chemistry
Breath Tests
Liver
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 14783231
- Volume :
- 40
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Liver international : official journal of the International Association for the Study of the Liver
- Accession number :
- edsair.doi.dedup.....798b19dd13af09dd9a8b184524bfc2b7