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Evidence for immunological (allergic) mechanisms in a subgroup of patients with phenprocoumon-induced liver disease
- Source :
- European Journal of Clinical Pharmacology, European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (12), pp.1195-1201. ⟨10.1007/s00228-009-0705-9⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- Purpose Phenprocoumon-induced liver injury is a rare complication of oral anticoagulation. The mechanisms leading to this side effect are not entirely clear. Here we present data that at least in a subgroup of patients in whom phenprocoumon-induced liver disease was suspected, immunological processes may play an important role. Patients and methods Thirty patients with suspected phenprocoumon-induced liver disease from different hospitals in Germany were analyzed. Peripheral blood mononuclear cells (PBMC) of these patients were tested in the lymphocyte transformation test (LTT) for reactivity with phenprocoumon in vitro. As controls, PBMC were isolated from ten individuals treated with phenprocoumon but without any side effects, and from ten healthy individuals who have never received the drug. Results Fifteen of the 30 patients had sensitized lymphocytes toward phenprocoumon as shown by LTT. Four patients had taken the drug for more than 5 years; in one patient, liver disease appeared after 1 day of phenprocoumon intake. There was no correlation between a positive LTT and clinical/ laboratory parameters. None of the 20 controls had sensitized lymphocytes toward phenprocoumon. Conclusions Applying the LTT, we were able to unravel the cause of suspected phenprocoumon-induced liver injury as a drug allergic reaction in 15 out of 30 analyzed patients.
- Subjects :
- Adult
Male
Allergy
Side effect
Drug-induced liver injury
medicine.drug_class
Lymphocyte transformation test
Lymphocyte Activation
Phenprocoumon
Drug Hypersensitivity
03 medical and health sciences
Liver disease
0302 clinical medicine
Immunopathology
Germany
Medicine
Humans
Pharmacology (medical)
Lymphocytes
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Aged
Pharmacology
Liver injury
Aged, 80 and over
0303 health sciences
business.industry
Anticoagulant
Anticoagulants
General Medicine
Middle Aged
medicine.disease
3. Good health
Immunology
030211 gastroenterology & hepatology
Female
Chemical and Drug Induced Liver Injury
business
Complication
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00316970 and 14321041
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Pharmacology, European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (12), pp.1195-1201. ⟨10.1007/s00228-009-0705-9⟩
- Accession number :
- edsair.doi.dedup.....798d9e1aa3ae0bb5f362c9246ac265e0