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Evaluation of Synergistic Effect of Combined Treatment with Linalool and Colistin on Multidrug-Resistant Acinetobacter baumannii to Expand Candidate for Therapeutic Option
- Source :
- Annals of Clinical Microbiology, Vol 23, Iss 1, Pp 11-20 (2020)
- Publication Year :
- 2020
- Publisher :
- The Korean Society of Clinical Microbiology, 2020.
-
Abstract
- Acinetobacter baumannii infection is a significant health problem worldwide due to increased drug resistance. The limited antimicrobial alternatives for the treatment of severe infections by multidrug-resistant A. baumanniiA. baumannii A. baumannii(MDRAB) make the search for other therapeutic options more urgent. Linalool, the major oil compound in Coriandrum sativum, was recently found to have high antibacterial activity against A. baumannii. The purpose of this study was to investigate the synergistic effect of linalool and colistin combinations against MDRAB and extensively drug-resistant A. baumanniiA. baumannii A. baumannii(XDRAB). A total of 51 strains of A. baumanniiA. baumannii A. baumanniiclinical isolates, consisting of 10 MDRAB and 41 XDRAB were tested. We determined the minimum inhibitory concentration (MIC) of linalool for the test strains using the broth microdilution method and searched for interactions using the time-kill assay. The time-kill assay showed that the linalool and colistin combination displayed a high rate of synergy (92.1%) (by synergy criteria 2), low rate of indifference (7.8%), and a high rate of bactericidal activity (74.5%) in the 51 clinical isolates of A. baumannii. The synergy rates for the linalool and colistin combination against MDRAB and XDRAB were 96% and 92.1%, respectively. No antagonism was observed for the linalool and colistin combination. The combination of linalool and colistin showed a high synergy rate, which may be beneficial for controlling MDRAB infections. Therefore, this combination is a good candidate for in vivo studies to assess its efficacy in the treatment of MDRAB infections.
- Subjects :
- linalool
lcsh:QR1-502
synergy
lcsh:Microbiology
Microbiology
chemistry.chemical_compound
Combined treatment
Linalool
polycyclic compounds
Medicine
colistin
biology
business.industry
General Medicine
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
biology.organism_classification
Acinetobacter baumannii
chemistry
Colistin
bacteria
acinetobacter baumannii
business
Multidrug resistant Acinetobacter baumannii
time-kill assay
medicine.drug
Subjects
Details
- ISSN :
- 22886850 and 22880585
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Annals of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....7998ab66060f3fb4b55ca2e42c600d53