Denitrative hydroxylation of unactivated nitroarenes

Authors :: Lee Duff
Harry Meakin
Adam Richardson
Andrew Greener
George Smith
Ivan Ocaña
Victor Chechik
Michael James
Source :: Duff, L, Meakin, H, Richardson, A, Greener, A J, Smith, G W A, Ocaña, I, Chechik, V & James, M J 2023, ' Denitrative hydroxylation of unactivated nitroarenes ', Chemistry – A European Journal . https://doi.org/10.1002/chem.202203807
Publication Year :: 2023
Abstract: A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalisation protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and computational studies suggest that unactivated nitroarenes may be substituted via an electron-catalysed radical-nucleophilic substitution (SRN1) chain mechanism.

Subjects :: denitrative functionalisation
Organic Chemistry
nitroarenes
radical anion
General Chemistry
Catalysis
S 1
hydroxylation

Language :: English
Database :: OpenAIRE
Journal :: Duff, L, Meakin, H, Richardson, A, Greener, A J, Smith, G W A, Ocaña, I, Chechik, V & James, M J 2023, ' Denitrative hydroxylation of unactivated nitroarenes ', Chemistry – A European Journal . https://doi.org/10.1002/chem.202203807
Accession number :: edsair.doi.dedup.....7998eafe6667c4a2d1341a3e3ec1a5ac
Full Text :: https://doi.org/10.1002/chem.202203807