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Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents
- Source :
- BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018), BMC Research Notes
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Objectives FTO rs9939609 variant has been shown to be associated with insulin resistance in Caucasian children. However, studies in Asia show inconsistent findings. We investigated the association between FTO rs9939609 polymorphisms and insulin resistance in obese female adolescents in Indonesia, a genetically distinct group within Asia. Results A total of 78 obese female adolescents participated in this study. The risk allele (A) frequency of FTO rs9939609 variant in Indonesian obese female adolescence was 44.2%. The frequency of insulin resistance was higher in the subjects with AA (54.6%) or AT (59.6%) than the subject with TT genotype (50%), but did not statistically different (p = 0.81 and p = 0.47, respectively). The insulin resistance rate was also higher in the risk allele (A) than the non-risk allele (T) subjects (0.58 vs. 0.55), but did not statistically different (p = 0.75). There was no association between FTO rs9939609 variant and body mass index, fasting glucose level, fasting insulin level, homeostatic model assessment of insulin resistance, and waist circumference (p > 0.05). In conclusion, FTO rs9939609 variant may not be associated with insulin resistance in Indonesian obese female adolescents. A multicenter study with a larger sample size is needed to clarify these findings.
- Subjects :
- 0301 basic medicine
Pediatric Obesity
medicine.medical_specialty
Waist
Adolescent
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
lcsh:Medicine
Common variant
General Biochemistry, Genetics and Molecular Biology
Fasting insulin
03 medical and health sciences
Insulin resistance
Internal medicine
Genotype
medicine
Humans
Allele
Child
lcsh:Science (General)
lcsh:QH301-705.5
Polymorphism, Genetic
Obese female adolescents
business.industry
lcsh:R
nutritional and metabolic diseases
General Medicine
rs9939609
medicine.disease
Research Note
030104 developmental biology
Endocrinology
lcsh:Biology (General)
Multicenter study
Indonesia
Homeostatic model assessment
Female
FTO
business
Body mass index
lcsh:Q1-390
Subjects
Details
- ISSN :
- 17560500
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- BMC Research Notes
- Accession number :
- edsair.doi.dedup.....79b4392d7fa19a79d9d61ddfc7ce0465