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Lung Cancer and Radon: Pooled Analysis of Uranium Miners Hired in 1960 or Later
- Source :
- Environmental health perspectives, vol 130, iss 5
- Publication Year :
- 2022
- Publisher :
- Environmental Health Perspectives, 2022.
-
Abstract
- BackgroundDespite reductions in exposure for workers and the general public, radon remains a leading cause of lung cancer. Prior studies of underground miners depended heavily upon information on deaths among miners employed in the early years of mine operations when exposures were high and tended to be poorly estimated.ObjectivesTo strengthen the basis for radiation protection, we report on the follow-up of workers employed in the later periods of mine operations for whom we have more accurate exposure information and for whom exposures tended to be accrued at intensities that are more comparable to contemporary settings.MethodsWe conducted a pooled analysis of cohort studies of lung cancer mortality among 57,873 male uranium miners in Canada, Czech Republic, France, Germany, and the United States, who were first employed in 1960 or later (thereby excluding miners employed during the periods of highest exposure and focusing on miners who tend to have higher quality assessments of radon progeny exposures). We derived estimates of excess relative rate per 100 working level months (ERR/100 WLM) for mortality from lung cancer.ResultsThe analysis included 1.9 million person-years of observation and 1,217 deaths due to lung cancer. The relative rate of lung cancer increased in a linear fashion with cumulative exposure to radon progeny (ERR/100 WLM=1.33; 95% CI: 0.89, 1.88). The association was modified by attained age, age at exposure, and annual exposure rate; for attained ages
- Subjects :
- Male
Lung Neoplasms
Neoplasms, Radiation-Induced
Radon Daughters
Health, Toxicology and Mutagenesis
Lung Cancer
Public Health, Environmental and Occupational Health
Miners
Toxicology
Medical and Health Sciences
Occupational Diseases
Radiation-Induced
Radon
Neoplasms
Occupational Exposure
General Earth and Planetary Sciences
Humans
Uranium
Lung
Environmental Sciences
Cancer
General Environmental Science
Subjects
Details
- ISSN :
- 15529924 and 00916765
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Environmental Health Perspectives
- Accession number :
- edsair.doi.dedup.....79c76f7629674f525f7cb6649ba7a228
- Full Text :
- https://doi.org/10.1289/ehp10669