Back to Search
Start Over
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers
- Source :
- NBCS Collaborators 2021, ' CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers ', British Journal of Cancer, vol. 124, no. 4, pp. 842-854 . https://doi.org/10.1038/s41416-020-01185-w, British Journal of Cancer, British Journal of Cancer, 124(4), 842-854. SPRINGERNATURE, Johnson, N, Maguire, S, Morra, A, Kapoor, P M, Tomczyk, K, Jones, M E, Schoemaker, M J, Gilham, C, Bolla, M K, Wang, Q, Dennis, J, Ahearn, T U, Andrulis, I L, Anton-culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Augustinsson, A, Baynes, C, Freeman, L E B, Beckmann, M W, Benitez, J, Bermisheva, M, Blomqvist, C, Boeckx, B, Bogdanova, N V, Bojesen, S E, Brauch, H, Brenner, H, Burwinkel, B, Campa, D, Canzian, F, Castelao, J E, Chanock, S J, Chenevix-trench, G, Clarke, C L, Conroy, D M, Couch, F J, Cox, A, Cross, S S, Czene, K, Dörk, T, Eliassen, A H, Engel, C, Evans, D G, Fasching, P A, Figueroa, J, Floris, G, Flyger, H, Gago-dominguez, M, Gapstur, S M, García-closas, M, Gaudet, M M, Giles, G G, Goldberg, M S, González-neira, A, Guénel, P, Hahnen, E, Haiman, C A, Håkansson, N, Hall, P, Hamann, U, Harrington, P A, Hart, S N, Hooning, M J, Hopper, J L, Howell, A, Hunter, D J, Jager, A, Jakubowska, A, John, E M, Kaaks, R, Keeman, R, Khusnutdinova, E, Kitahara, C M, Kosma, V, Koutros, S, Kraft, P, Kristensen, V N, Kurian, A W, Lambrechts, D, Le Marchand, L, Linet, M, Lubiński, J, Mannermaa, A, Manoukian, S, Margolin, S, Martens, J W M, Mavroudis, D, Mayes, R, Meindl, A, Milne, R L, Neuhausen, S L, Nevanlinna, H, Newman, W G, Nielsen, S F, Nordestgaard, B G, Obi, N, Olshan, A F, Olson, J E, Olsson, H, Orban, E, Park-simon, T, Peterlongo, P, Plaseska-karanfilska, D, Pylkäs, K, Rennert, G, Rennert, H S, Ruddy, K J, Saloustros, E, Sandler, D P, Sawyer, E J, Schmutzler, R K, Scott, C, Shu, X, Simard, J, Smichkoska, S, Sohn, C, Southey, M C, Spinelli, J J, Stone, J, Tamimi, R M, Taylor, J A, Tollenaar, R A E M, Tomlinson, I, Troester, M A, Truong, T, Vachon, C M, Van Veen, E M, Wang, S S, Weinberg, C R, Wendt, C, Wildiers, H, Winqvist, R, Wolk, A, Zheng, W, Ziogas, A, Dunning, A M, Pharoah, P D P, Easton, D F, Howie, A F, Peto, J, Dos-santos-silva, I, Swerdlow, A J, Chang-claude, J, Schmidt, M K, Orr, N & Fletcher, O 2021, ' CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-01185-w, British Journal of Cancer, 124(4), 842-854. Nature Publishing Group, Johnson, N, Maguire, S, Morra, A, Kapoor, P M, Tomczyk, K, Jones, M E, Schoemaker, M J, Gilham, C, Bolla, M K, Wang, Q, Dennis, J, Ahearn, T U, Andrulis, I L, Anton-Culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Augustinsson, A, Baynes, C, Freeman, L E B, Beckmann, M W, Benitez, J, Bermisheva, M, Blomqvist, C, Boeckx, B, Bogdanova, N V, Bojesen, S E, Brauch, H, Brenner, H, Burwinkel, B, Campa, D, Canzian, F, Castelao, J E, Chanock, S J, Chenevix-Trench, G, Clarke, C L, Børresen-Dale, A L, Alnæs, G I G, Sahlberg, K K, Ottestad, L, Kåresen, R, Schlichting, E, Holmen, M M, Sauer, T, Haakensen, V, Riis, M, Flyger, H, Nielsen, S F, Nordestgaard, B G, Scott, C, NBCS Collaborators, AOCS Group, ABCTB Investigators & kConFab Investigators 2021, ' CYP3A7*1C allele : linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers ', British Journal of Cancer, vol. 124, no. 4, pp. 842-854 . https://doi.org/10.1038/s41416-020-01185-w
- Publication Year :
- 2021
-
Abstract
- Background Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Methods We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Results For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (−49.2%, 95% CI −56.1% to −41.1%, P = 3.1 × 10–18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (−26.7%, 95% CI −39.4% to −11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82–0.91, P = 6.9 × 10–8). Conclusions The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.
- Subjects :
- Cancer Research
CYP3A5
Physiology
Genome-wide association study
Breast cancer
0302 clinical medicine
Epidemiology
Receptors
IMPUTATION
Medicine
Cytochrome P-450 CYP3A
Cancer genetics
Progesterone
0303 health sciences
article
1112 Oncology and Carcinogenesis, 1117 Public Health and Health Services
AOCS Group
Single Nucleotide
humanities
3. Good health
Receptors, Estrogen
Oncology
Hormone receptor
030220 oncology & carcinogenesis
kConFab Investigators
Pregnanediol
Female
Receptors, Progesterone
Medical Genetics
medicine.medical_specialty
Estrone
Urinary system
3122 Cancers
ABCTB Investigators
631/67/2324
Breast Neoplasms
Polymorphism, Single Nucleotide
NBCS Collaborators
03 medical and health sciences
Cancer epidemiology
SDG 3 - Good Health and Well-being
631/67/68
Humans
Oncology & Carcinogenesis
Allele
GENOME-WIDE ASSOCIATION
Polymorphism
CYP3A7
Alleles
030304 developmental biology
Medicinsk genetik
business.industry
631/67/1347
medicine.disease
Case-Control Studies
Genome-Wide Association Study
Premenopause
Estrogen
business
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Database :
- OpenAIRE
- Journal :
- NBCS Collaborators 2021, ' CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers ', British Journal of Cancer, vol. 124, no. 4, pp. 842-854 . https://doi.org/10.1038/s41416-020-01185-w, British Journal of Cancer, British Journal of Cancer, 124(4), 842-854. SPRINGERNATURE, Johnson, N, Maguire, S, Morra, A, Kapoor, P M, Tomczyk, K, Jones, M E, Schoemaker, M J, Gilham, C, Bolla, M K, Wang, Q, Dennis, J, Ahearn, T U, Andrulis, I L, Anton-culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Augustinsson, A, Baynes, C, Freeman, L E B, Beckmann, M W, Benitez, J, Bermisheva, M, Blomqvist, C, Boeckx, B, Bogdanova, N V, Bojesen, S E, Brauch, H, Brenner, H, Burwinkel, B, Campa, D, Canzian, F, Castelao, J E, Chanock, S J, Chenevix-trench, G, Clarke, C L, Conroy, D M, Couch, F J, Cox, A, Cross, S S, Czene, K, Dörk, T, Eliassen, A H, Engel, C, Evans, D G, Fasching, P A, Figueroa, J, Floris, G, Flyger, H, Gago-dominguez, M, Gapstur, S M, García-closas, M, Gaudet, M M, Giles, G G, Goldberg, M S, González-neira, A, Guénel, P, Hahnen, E, Haiman, C A, Håkansson, N, Hall, P, Hamann, U, Harrington, P A, Hart, S N, Hooning, M J, Hopper, J L, Howell, A, Hunter, D J, Jager, A, Jakubowska, A, John, E M, Kaaks, R, Keeman, R, Khusnutdinova, E, Kitahara, C M, Kosma, V, Koutros, S, Kraft, P, Kristensen, V N, Kurian, A W, Lambrechts, D, Le Marchand, L, Linet, M, Lubiński, J, Mannermaa, A, Manoukian, S, Margolin, S, Martens, J W M, Mavroudis, D, Mayes, R, Meindl, A, Milne, R L, Neuhausen, S L, Nevanlinna, H, Newman, W G, Nielsen, S F, Nordestgaard, B G, Obi, N, Olshan, A F, Olson, J E, Olsson, H, Orban, E, Park-simon, T, Peterlongo, P, Plaseska-karanfilska, D, Pylkäs, K, Rennert, G, Rennert, H S, Ruddy, K J, Saloustros, E, Sandler, D P, Sawyer, E J, Schmutzler, R K, Scott, C, Shu, X, Simard, J, Smichkoska, S, Sohn, C, Southey, M C, Spinelli, J J, Stone, J, Tamimi, R M, Taylor, J A, Tollenaar, R A E M, Tomlinson, I, Troester, M A, Truong, T, Vachon, C M, Van Veen, E M, Wang, S S, Weinberg, C R, Wendt, C, Wildiers, H, Winqvist, R, Wolk, A, Zheng, W, Ziogas, A, Dunning, A M, Pharoah, P D P, Easton, D F, Howie, A F, Peto, J, Dos-santos-silva, I, Swerdlow, A J, Chang-claude, J, Schmidt, M K, Orr, N & Fletcher, O 2021, ' CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-01185-w, British Journal of Cancer, 124(4), 842-854. Nature Publishing Group, Johnson, N, Maguire, S, Morra, A, Kapoor, P M, Tomczyk, K, Jones, M E, Schoemaker, M J, Gilham, C, Bolla, M K, Wang, Q, Dennis, J, Ahearn, T U, Andrulis, I L, Anton-Culver, H, Antonenkova, N N, Arndt, V, Aronson, K J, Augustinsson, A, Baynes, C, Freeman, L E B, Beckmann, M W, Benitez, J, Bermisheva, M, Blomqvist, C, Boeckx, B, Bogdanova, N V, Bojesen, S E, Brauch, H, Brenner, H, Burwinkel, B, Campa, D, Canzian, F, Castelao, J E, Chanock, S J, Chenevix-Trench, G, Clarke, C L, Børresen-Dale, A L, Alnæs, G I G, Sahlberg, K K, Ottestad, L, Kåresen, R, Schlichting, E, Holmen, M M, Sauer, T, Haakensen, V, Riis, M, Flyger, H, Nielsen, S F, Nordestgaard, B G, Scott, C, NBCS Collaborators, AOCS Group, ABCTB Investigators & kConFab Investigators 2021, ' CYP3A7*1C allele : linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers ', British Journal of Cancer, vol. 124, no. 4, pp. 842-854 . https://doi.org/10.1038/s41416-020-01185-w
- Accession number :
- edsair.doi.dedup.....79c80976e607f7f5adac25ce2443816d