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Altered expression of genes related to innate antifungal immunity in the absence of galectin-3
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Virulence, Vol 12, Iss 1, Pp 981-988 (2021), Virulence, article-version (VoR) Version of Record
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Galectin-3 (Gal-3) is the most studied member of the animal galectin family, which comprises β-galactoside-binding lectins and participates in several cellular events. Its expression in cells involved in innate and adaptive immunity is related to anti- and proinflammatory functions, signaling an important role in inflammatory, infectious, and tumorigenesis processes. Mice deficient in Gal-3 exhibit important phenotypes, but it is unclear whether these phenotypes reflect an impairment of the functions of this protein. Gal-3 plays an important role in modulating the immune response to different pathogenic microorganisms. However, the role of Gal-3 in immunity to infection is still poorly understood. Therefore, we investigated the effects of Gal-3 deletion on the expression of genes involved in the innate immune response in the lungs, spleens, and brains of Gal-3 KO mice. Gene profiling expression analysis suggested that Gal-3 deletion resulted in differentially modulated expression of the genes encoding beta-glucan, mannose and chitin-responsive pattern recognition receptors, signal transduction, inflammation, and phagocytosis. Our data thus suggest the importance of Gal-3 expression in the host innate immune system.
- Subjects :
- Microbiology (medical)
Antifungal
Antifungal Agents
animal structures
medicine.drug_class
Galectin 3
Galectins
Immunology
Infectious and parasitic diseases
RC109-216
Adaptive Immunity
Biology
Microbiology
gene knockout
Mice
03 medical and health sciences
Immunity
galectin-3
Gene expression
otorhinolaryngologic diseases
medicine
Animals
Gene
Gene knockout
030304 developmental biology
Galectin
0303 health sciences
Innate immune system
030306 microbiology
EXPRESSÃO GÊNICA
Immunity, Innate
Cell biology
stomatognathic diseases
Infectious Diseases
Galectin-3
innate immune response
gene expression
Parasitology
antifungal immunity
Research Article
Research Paper
Subjects
Details
- ISSN :
- 21505608 and 21505594
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Virulence
- Accession number :
- edsair.doi.dedup.....79e567f10299bc01e968967522e05b3d