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A Case of Renal Primitive Neuroectodermal Tumor Confirmed by Fluorescence in situ Hybridization
- Source :
- Case Reports in Oncology, Vol 8, Iss 1, Pp 205-211 (2015), Case Reports in Oncology
- Publication Year :
- 2015
- Publisher :
- S. Karger AG, 2015.
-
Abstract
- Primitive neuroectodermal tumor (PNET) is a member of the Ewing's sarcoma family of tumors (ESFT). We report a case of PNET in a 66-year-old male who presented with a large solid tumor within the parenchyma of the middle pole of the left kidney with metastases to the left adrenal gland and right ischium. A fine-needle biopsy was performed and showed a small round cell tumor. Results of immunohistochemical staining suggested this tumor belonged to ESFT. Preoperative VDC-IE (combined vincristine, doxorubicin and cyclophosphamide followed by another combination of ifosfamide and etoposide) chemotherapy and left radical nephrectomy and adrenalectomy were performed. The histopathological findings of the resected tumor were similar to those in the biopsy specimen, but the results of AE1/AE3 were different. For the diagnosis, fluorescence in situ hybridization was performed. Split signals of the EWSR1 gene were detected, and transmission electron microscopy showed neuroendocrine granules and microtubules. The final diagnosis of this tumor was PNET of the kidney.
- Subjects :
- Pathology
medicine.medical_specialty
Vincristine
Ifosfamide
medicine.diagnostic_test
business.industry
Fluorescence in situ hybridization
medicine.medical_treatment
Kidney
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
lcsh:RC254-282
Primitive neuroectodermal tumor
Nephrectomy
VDC-IE chemotherapy
Oncology
Biopsy
medicine
Sarcoma
Published online: April, 2015
business
Etoposide
medicine.drug
Subjects
Details
- ISSN :
- 16626575
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Case Reports in Oncology
- Accession number :
- edsair.doi.dedup.....79eb714f40606ff73b2967e6807c0f01