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Posttreatment Lyme Disease Syndrome—What It Might Be and What It Is Not
- Source :
- Pediatric Infectious Disease Journal. 40:S31-S34
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Lyme disease is a multisystem disease caused by Borrelia burgdorferi infection and accounts for well-defined manifestations, appearing either at an early or late stage. Appropriate antibiotic therapy generally leads to a favorable outcome. Still, unspecific persisting symptoms such as fatigue, myalgia, arthralgia or cognitive dysfunction are reported by several patients months to years after adequate treatment. Their underlying pathophysiologic mechanism is unclear. However, there is no evidence for microbiological persistence in these cases and attempts to resolve the symptoms by repeated or prolonged antibiotic treatment have not been convincingly successful, but they may rather be harmful. To narrow down the controversially handled entity of posttreatment Lyme disease syndrome (PTLDS) and to avoid overdiagnosis and overtreatment, case definitions have been proposed, acknowledging PTLDS as a complex of nonspecific, subjective symptoms, which are neither caused by ongoing infection nor by any other identifiable disease. PTLDS is mainly a diagnosis of exclusion and requires careful evaluation of differential diagnosis followed by counseling about optimal management in light of missing specific therapeutic options.
- Subjects :
- Microbiology (medical)
myalgia
medicine.medical_specialty
Overdiagnosis
medicine.drug_class
Antibiotics
Disease
03 medical and health sciences
0302 clinical medicine
Lyme disease
030225 pediatrics
Humans
Medicine
030212 general & internal medicine
Intensive care medicine
Lyme Disease
Post-Lyme Disease Syndrome
Overtreatment
business.industry
Borrelia Burgdorferi Infection
medicine.disease
Diagnosis of exclusion
Infectious Diseases
Pediatrics, Perinatology and Child Health
Symptom Assessment
medicine.symptom
Differential diagnosis
business
Subjects
Details
- ISSN :
- 08913668
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Pediatric Infectious Disease Journal
- Accession number :
- edsair.doi.dedup.....79fe131009af33514d33ff10b8946ee6
- Full Text :
- https://doi.org/10.1097/inf.0000000000002772