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The Suppressive Effect of Leucine-Rich Glioma Inactivated 3 (LGI3) Peptide on Impaired Skin Barrier Function in a Murine Model Atopic Dermatitis
- Source :
- Pharmaceutics, Volume 12, Issue 8, Pharmaceutics, Vol 12, Iss 750, p 750 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- This study aimed to restore the skin barrier function from atopic dermatitis (AD) via treatment with leucine-rich glioma inactivated 3 (LGI3) peptide. Male NC/Nga mice (7 weeks, 20 g) were randomly allocated into three groups (control, AD, and LGI3 group). After induction of AD skin lesions with Dermatophagoides farinae ointment, mice were treated with LGI3. The clinical score of AD was the highest and the dorsal skin thickness was the thickest in the AD group. In contrast, LGI3 treatment improved the clinical score and the dorsal skin thickness compared to the AD model. LGI3 treatment suppressed histopathological thickness of the epithelial cell layer of the dorsal skin. LGI3 treatment could indirectly reduce mast cell infiltration through restoring the barrier function of the skin. Additionally, the filaggrin expression was increased in immunohistochemical evaluation. In conclusion, the ameliorating effect and maintaining skin barrier homeostasis in the AD murine model treated with LGI3 could be attributed to complete re-epithelialization of keratinocytes. Hence, LGI3 might be considered as a new potential therapeutic target for restoring skin barrier function in AD.
- Subjects :
- filaggrin
Keratosis
Pharmaceutical Science
lcsh:RS1-441
Pharmacology
Article
lcsh:Pharmacy and materia medica
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Glioma
Medicine
leucine-rich glioma inactivated 3 (LGI3) peptide
skin barrier
Barrier function
030304 developmental biology
0303 health sciences
integumentary system
atopic dermatitis
business.industry
Atopic dermatitis
medicine.disease
Epithelium
medicine.anatomical_structure
keratosis
Immunohistochemistry
business
Homeostasis
Filaggrin
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....7a004289eac637910a7a3913159c697a
- Full Text :
- https://doi.org/10.3390/pharmaceutics12080750