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Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats

Authors :
Md. Raihan Uzzaman Prince
S. M. Neamul Kabir Zihad
Puja Ghosh
Nazifa Sifat
Razina Rouf
Gazi Mohammad Al Shajib
Md. Ashraful Alam
Jamil A. Shilpi
Shaikh J. Uddin
Source :
Frontiers in Nutrition, Frontiers in Nutrition, Vol 8 (2021)
Publication Year :
2021
Publisher :
Frontiers Media SA, 2021.

Abstract

Amaranthus spinosus is a common vegetable of Bangladesh and well-known for its ethnomedicinal uses. In this study, we have evaluated the ability of powdered supplementation, methanol extract, and aqueous extract of A. spinosus in attenuating in high-carbohydrate-high-fat (HCHF) diet-induced obesity and associated metabolic disorders in female obese rates. Several parameters have been analyzed in this study including body weight, organ weight, fat deposition, glycemic status, lipid levels, hepatic and renal biomarkers, hepatic antioxidant status, and hepatosteatosis. All three samples of A. spinosus significantly reduced weight gain, organ weight, and abdominal fat deposition. Improved glucose tolerance and lipid parameters were seen in obese rats administered with A. spinosus powder, methanol extract, and aqueous extract. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatine kinase levels were normalized by the test samples. A. spinosus boosted hepatic antioxidant levels including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Histopathology of liver tissue revealed increased fat infiltration and higher steatosis score in HCHF diet-fed obese rats which was brought down by A. spinosus. Analyzing all the results it can be concluded that this medicinal herb is beneficial in the management of obesity and obesity-induced metabolic disorders, making it a prospective food supplement.

Details

Language :
English
ISSN :
2296861X
Volume :
8
Database :
OpenAIRE
Journal :
Frontiers in Nutrition
Accession number :
edsair.doi.dedup.....7a06b89365d712c6612304607d127f19
Full Text :
https://doi.org/10.3389/fnut.2021.653918