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Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018), Nature Communications, Nature communications, vol 9, iss 1
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge for drug transportation. In tumour microenvironment, pPhD NPs responsively transform to full API nanotheranostics with ultra-small size and higher surface charge, which dramatically facilitate the tumour penetration and cell internalisation. pPhD NPs enable visualisation of biodistribution by near-infrared fluorescence imaging, tumour accumulation and therapeutic effect by magnetic resonance imaging. Moreover, the synergistic photothermal-, photodynamic- and chemo-therapies achieve a 100% complete cure rate on both subcutaneous and orthotopic oral cancer models. This nanoplatform with powerful delivery efficiency and versatile theranostic functions shows enormous potentials to improve cancer treatment.<br />Size and charge can significantly affect delivery of therapeutic agents to tumours. Here, the authors report on nanoparticles optimised for delivery to the tumour which release smaller particles and change charge in the tumour microenvironment to optimise tumour penetration and cellular uptake.
- Subjects :
- Fluorescence-lifetime imaging microscopy
Cure rate
Theranostic Nanomedicine
Nude
General Physics and Astronomy
Apoptosis
02 engineering and technology
01 natural sciences
Mice
Nanotechnology
lcsh:Science
Cancer
screening and diagnosis
Tumor
Multidisciplinary
Chemistry
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
3. Good health
Cancer treatment
Detection
5.1 Pharmaceuticals
Carcinoma, Squamous Cell
Biomedical Imaging
Nanomedicine
Female
Mouth Neoplasms
Development of treatments and therapeutic interventions
0210 nano-technology
Biodistribution
Science
Mice, Nude
Bioengineering
010402 general chemistry
Article
General Biochemistry, Genetics and Molecular Biology
Cell Line
Cell Line, Tumor
Animals
Humans
Carcinoma
General Chemistry
Phototherapy
Photothermal therapy
4.1 Discovery and preclinical testing of markers and technologies
0104 chemical sciences
Good Health and Well Being
Squamous Cell
Delivery efficiency
Nanoparticles
lcsh:Q
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....7a0c9b639d9a4a18b7f53fe9cbf62fea