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Evidence Map of Pancreatic Surgery–A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS)
- Source :
- Zaguán. Repositorio Digital de la Universidad de Zaragoza, instname, Surgery (United States), 170(5), 1517-1524. Mosby Inc., SURGERY
- Publication Year :
- 2021
-
Abstract
- Background: Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. Methods: PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all randomized controlled trials and systematic reviews on pancreatic surgery. Outcomes from every existing randomized controlled trial were extracted, and trial quality was assessed. Systematic reviews were used to identify an absence of randomized controlled trials. Randomized controlled trials and systematic reviews on identical subjects were grouped according to research topics. A web-based evidence map modeled after a mind map was created to visualize existing evidence. Meta-analyses of specific outcomes of pancreatic surgery were performed for all research topics with more than 3 randomized controlled trials. For partial pancreatoduodenectomy and distal pancreatectomy, pooled benchmarks for outcomes were calculated with a 99% confidence interval. The evidence map undergoes regular updates. Results: Out of 30, 860 articles reviewed, 328 randomized controlled trials on 35, 600 patients and 332 systematic reviews were included and grouped into 76 research topics. Most randomized controlled trials were from Europe (46%) and most systematic reviews were from Asia (51%). A living meta-analysis of 21 out of 76 research topics (28%) was performed and included in the web-based evidence map. Evidence gaps were identified in 11 out of 76 research topics (14%). The benchmark for mortality was 2% (99% confidence interval: 1%–2%) for partial pancreatoduodenectomy and
- Subjects :
- medicine.medical_specialty
MEDLINE
030230 surgery
Pancreatic surgery
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Humans
Medicine
Pancreas
Digestive System Surgical Procedures
Pancreatic Surgery
Evidence-Based Medicine
business.industry
General surgery
Evidence-based medicine
Confidence interval
ddc
3. Good health
Clinical research
Systematic review
030220 oncology & carcinogenesis
Surgery
Distal pancreatectomy
business
Subjects
Details
- Language :
- English
- ISSN :
- 00396060
- Database :
- OpenAIRE
- Journal :
- Zaguán. Repositorio Digital de la Universidad de Zaragoza, instname, Surgery (United States), 170(5), 1517-1524. Mosby Inc., SURGERY
- Accession number :
- edsair.doi.dedup.....7a1224896bc761c5959a795158adc802