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Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound
- Source :
- Optics express. 17(15)
- Publication Year :
- 2009
-
Abstract
- Four very low birth weight, very premature infants were monitored during a 12 degrees postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) to measure macrovascular blood flow velocity in the middle cerebral artery. DCS data correlated significantly with peak systolic, end diastolic, and mean velocities measured by TCD (p(A) =0.036, 0.036, 0.047). Moreover, population averaged TCD and DCS data yielded no significant hemodynamic response to this postural change (p0.05). We thus demonstrate feasibility of DCS in this population, we show correlation between absolute measures of blood flow from DCS and blood flow velocity from TCD, and we do not detect significant changes in CBF associated with a small postural change (12 degrees ) in these patients.
- Subjects :
- Middle Cerebral Artery
Optics and Photonics
Light
Haemodynamic response
Ultrasonography, Doppler, Transcranial
Population
Hemodynamics
Article
Optics
medicine.artery
medicine
Humans
Scattering, Radiation
Ultrasonics
education
education.field_of_study
business.industry
Microcirculation
Infant, Newborn
Brain
Blood flow
Laser Doppler velocimetry
Atomic and Molecular Physics, and Optics
Transcranial Doppler
Cerebral blood flow
Spectrophotometry
Cerebrovascular Circulation
Middle cerebral artery
cardiovascular system
business
Infant, Premature
Subjects
Details
- ISSN :
- 10944087
- Volume :
- 17
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Optics express
- Accession number :
- edsair.doi.dedup.....7a1df59c726c29d5b073ba3aa13e76e8