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Fast high-resolution metabolic imaging of acute stroke with 3D magnetic resonance spectroscopy
- Source :
- Brain
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Li et al. demonstrate the feasibility of rapid, high-resolution, near whole-brain 3D MR spectroscopic imaging in acute stroke within real-world clinical environments. Metabolic maps obtained at 3 mm spatial resolution show that the lactate signal can distinguish between areas of infarction, penumbra and oligaemia.<br />Impaired oxygen and cellular metabolism is a hallmark of ischaemic injury in acute stroke. Magnetic resonance spectroscopic imaging (MRSI) has long been recognized as a potentially powerful tool for non-invasive metabolic imaging. Nonetheless, long acquisition time, poor spatial resolution, and narrow coverage have limited its clinical application. Here we investigated the feasibility and potential clinical utility of rapid, high spatial resolution, near whole-brain 3D metabolic imaging based on a novel MRSI technology. In an 8-min scan, we simultaneously obtained 3D maps of N-acetylaspartate and lactate at a nominal spatial resolution of 2.0 × 3.0 × 3.0 mm3 with near whole-brain coverage from a cohort of 18 patients with acute ischaemic stroke. Serial structural and perfusion MRI was used to define detailed spatial maps of tissue-level outcomes against which high-resolution metabolic changes were evaluated. Within hypoperfused tissue, the lactate signal was higher in areas that ultimately infarcted compared with those that recovered (P
- Subjects :
- Adult
Male
Magnetic Resonance Spectroscopy
Perfusion Imaging
Neuroimaging
030218 nuclear medicine & medical imaging
Cohort Studies
03 medical and health sciences
Imaging, Three-Dimensional
N-acetylaspartate
0302 clinical medicine
Ischaemic stroke
Image Processing, Computer-Assisted
Medical imaging
Humans
Medicine
Lactic Acid
Prospective Studies
Aged
Ischemic Stroke
Acute stroke
Aged, 80 and over
Aspartic Acid
ischaemic stroke
lactate
AcademicSubjects/SCI01870
business.industry
Penumbra
Metabolic imaging
Magnetic resonance spectroscopic imaging
penumbra
Nuclear magnetic resonance spectroscopy
Middle Aged
Magnetic Resonance Imaging
magnetic resonance spectroscopic imaging
Female
Spin Labels
AcademicSubjects/MED00310
Neurology (clinical)
Nuclear medicine
business
Perfusion
030217 neurology & neurosurgery
Reports
Subjects
Details
- ISSN :
- 14602156 and 00068950
- Volume :
- 143
- Database :
- OpenAIRE
- Journal :
- Brain
- Accession number :
- edsair.doi.dedup.....7a23dacbb4274f9bab8964156daa6129