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Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder
- Source :
- Journal of Neuroimmunology. (1-2):58-66
- Publisher :
- Elsevier B.V.
-
Abstract
- Our objective was to evaluate the effect of stress-related dose of dopamine (DA) on the in vitro proliferation and cytokine production in polyclonally-activated T cells from healthy individuals or individuals with generalized anxiety disorder (GAD). Our results demonstrated that cell cultures from GAD group proliferated less following T cell activation, as compared with control group. The addition of DA reduced the proliferative response in cell cultures from healthy but not from GAD individuals. The cytokine profile in GAD individuals revealed Th1 and Th2 deficiencies associated with a dominant Th17 phenotype, which was enhanced by DA. A similar DA-induced immunomodulation was also observed in PPD-activated cell cultures from GAD individuals. Unlike the control, DA-enhanced Th17 cytokine production in GAD individuals was not affected by glucocorticoid. In conclusion, our results show that the T cell functional dysregulation in GAD individuals is significantly amplified by DA. These immune abnormalities can have impact in increasing the susceptibility of individuals with anxiety disorders to infectious diseases and inflammatory/autoimmune disorders.
- Subjects :
- Male
medicine.medical_treatment
Dopamine
Generalized anxiety disorder
IL-10/TGF-β
Glucocorticoid
Immunology and Allergy
Cells, Cultured
Flow Cytometry
Anxiety Disorders
Up-Regulation
Cytokine
medicine.anatomical_structure
Phenotype
Neurology
Anxiety
Cytokines
Female
medicine.symptom
Psychology
medicine.drug
Adult
medicine.medical_specialty
endocrine system
Adolescent
Cell Survival
T cell
Immunology
Th17/Th1
Clinical Neurology
Enzyme-Linked Immunosorbent Assay
Tritium
Tuberculin
Young Adult
Immune system
Antigen
Antigens, CD
Internal medicine
medicine
Humans
Phytohemagglutinins
Glucocorticoids
Cell Proliferation
medicine.disease
Endocrinology
Th17 Cells
Neurology (clinical)
Mitogens
Thymidine
Subjects
Details
- Language :
- English
- ISSN :
- 01655728
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....7a3d9e67d479b4b6913488232f80c590
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2011.06.009