Back to Search Start Over

Imidazopyridyl compounds as aldosterone synthase inhibitors

Authors :
Brent R. Whitehead
Michael M.-C. Lo
Amjad Ali
Min K. Park
Scott B. Hoyt
Yusheng Xiong
Jiaqiang Cai
Emma Carswell
Andrew Cooke
John MacLean
Paul Ratcliffe
John Robinson
D. Jonathan Bennett
Joseph A. Clemas
Tom Wisniewski
Mary Struthers
Doris Cully
Douglas J. MacNeil
Source :
Bioorganic & Medicinal Chemistry Letters. 27:143-146
Publication Year :
2017
Publisher :
Elsevier BV, 2017.

Abstract

This invention relates to triazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Details

ISSN :
0960894X
Volume :
27
Database :
OpenAIRE
Journal :
Bioorganic & Medicinal Chemistry Letters
Accession number :
edsair.doi.dedup.....7a3f370cc26a7dc473d889e2fc7da4ea