Back to Search
Start Over
Imidazopyridyl compounds as aldosterone synthase inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 27:143-146
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- This invention relates to triazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
- Subjects :
- Male
Aldosterone synthase
medicine.medical_specialty
Pyridines
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
01 natural sciences
Biochemistry
Structure-Activity Relationship
Cricetulus
Internal medicine
Drug Discovery
medicine
Animals
Cytochrome P-450 CYP11B2
Humans
Rats, Wistar
Molecular Biology
biology
010405 organic chemistry
Chemistry
Organic Chemistry
Imidazoles
Macaca mulatta
humanities
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Endocrinology
Microsomes, Liver
biology.protein
Steroid 11-beta-Hydroxylase
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....7a3f370cc26a7dc473d889e2fc7da4ea