Back to Search
Start Over
PROLACTIN-SECRETING PITUITARY ADENOMAS: PROLACTIN DYNAMICS BEFORE AND AFTER TRANSSPHENOIDAL SURGERY
- Source :
- Acta Endocrinologica. 91:397-409
- Publication Year :
- 1979
- Publisher :
- Oxford University Press (OUP), 1979.
-
Abstract
- Twenty women with hyperprolactinaemia secondary to a pituitary adenoma were studied before and after selective transsphenoidal removal of the tumour. Pre-operatively, thyrotrophin-releasing hormone (TRH) (200 μg iv) and metoclopramide (MCP) (10 mg po) did not produce a positive PRL response in the tumour patients. By contrast, 14 post-partum lactating women, who were used as controls, exhibited a positive response to MCP administration. Methergoline (4 mg po) was shown to decrease serum PRL levels in 8 normal subjects, in 6 puerperal women, and 9 of 10 tumour patients. Bromoergocriptine (CB-154, 2.5 mg po) decreased serum PRL levels in 10 tumour patients. Following transsphenoidal removal of the adenoma serum PRL levels were reduced in all patients, and returned to normal in 14 patients. Prognostics for completely normalizing PRL secretion after transsphenoidal surgery is better when initial serum PRL levels are below 200 ng/ml. After surgery all hyperprolactinaemic patients failed to show a positive PRL response to TRH and MCP. Nine normoprolactinaemic patients had a positive response to both stimuli while 3 patients failed to show a positive response immediately following surgery. Long-term studies, however, showed that a positive PRL response was obtained in all patients tested 8–14 months after treatment. A positive PRL response to methergoline and bromocriptine was observed post-operatively in the patients tested regardless of their basal PRL level. Data from this study indicate that surgically proven PRL-secreting adenomas are invariably associated with negative PRL responses to TRH and MCP. The normalization of the prolactin regulation after surgery points toward the intrapituitary localization of the lesion associated with PRL-secreting adenomas.
- Subjects :
- Adenoma
Adult
endocrine system
medicine.medical_specialty
Adolescent
endocrine system diseases
Metoclopramide
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Hypothalamus
Radioimmunoassay
Endocrinology
Pregnancy
Pituitary adenoma
Internal medicine
medicine
Humans
Pituitary Neoplasms
Thyrotropin-Releasing Hormone
Bromocriptine
Transsphenoidal surgery
business.industry
Postpartum Period
Hyperprolactinaemia
General Medicine
medicine.disease
Prolactin
Pituitary Gland
Metergoline
Female
business
hormones, hormone substitutes, and hormone antagonists
Hormone
medicine.drug
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Acta Endocrinologica
- Accession number :
- edsair.doi.dedup.....7a53d202d92938c0385693757ef5e68c