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Systematic review and meta-analysis of liver transplantation using grafts from deceased donors aged over 70 years
- Source :
- Clinical Transplantation. 31:e13139
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Due to the current organ shortage, nearly 20% of patients die waiting for a liver transplant (LT). The average donor age is on the rise, and grafts from elderly donors are offered as extended criteria grafts.This is a meta-analysis comparing the outcome differences of adult patients undergoing LT using grafts from70-year-old donors vs70-year-old donors. The primary end-points were graft and patient survival. Secondary outcomes were biliary and vascular complications as well as graft function. The odds ratio (OR) is a summary statistic with the corresponding 95% confidence interval; P .05 was considered to be statistically significant.Eight nonrandomized comparative studies with 4376 LT recipients were included. About 79.9% and 20.1% of the grafts were from70-year-old and70-year-old donors, respectively. Graft survival at 1 year was similar between the two groups (P = .11), but there was better 3-year and 5-year graft survival in the70-year-old group (P = .006 and P .0001, respectively). Patient survival was also similar between the groups at 1 year (P = .54), but with better survival at 3-year and 5-year follow-ups (P = .007 and P .0001, respectively) in the70-year-old group. There were no statistically significant differences in the incidence of biliary, vascular, and graft functional-related complications.Liver grafts from selected70-year-old donors do not pose added organ-specific risks and thus have comparable transplantation outcomes.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Economic shortage
030230 surgery
Liver transplantation
03 medical and health sciences
0302 clinical medicine
Cadaver
medicine
Humans
Aged
Transplantation
Adult patients
business.industry
Incidence (epidemiology)
Age Factors
Patient survival
Odds ratio
Tissue Donors
Confidence interval
Liver Transplantation
Surgery
surgical procedures, operative
Meta-analysis
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 09020063
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Clinical Transplantation
- Accession number :
- edsair.doi.dedup.....7a5faf77bcefa05343a1fa760bbf2742