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Seronegative neurobrucellosis—do we need new neurobrucellosis criteria?
- Source :
- International Journal of Infectious Diseases, Vol 111, Iss, Pp 124-126 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Neurobrucellosis presents in various clinical forms and should always be considered in neurological patients in highly endemic areas such as the Mediterranean basin. Establishing a diagnosis can be challenging since serological testing can sometimes yield negative results. We present a rare case of a seronegative relapse of neurobrucellosis in a patient who had been successfully treated for systemic brucellosis. Oligoclonal bands, an agglutination test, and 16S rRNA sequencing of cerebrospinal fluid proved essential in unmasking a confined central nervous system relapse. This case reinforces the need for establishing diagnostic criteria for neurobrucellosis, which could potentially include oligoclonal bands and an agglutination test on the cerebrospinal fluid.
- Subjects :
- Microbiology (medical)
Oligoclonal bands
business.industry
Brucellosis
Infectious and parasitic diseases
RC109-216
General Medicine
medicine.disease
Serology
Agglutination tests
RNA, ribosomal, 16S
Infectious Diseases
Cerebrospinal fluid
Direct agglutination test
Rare case
Immunology
medicine
business
RNA RIBOSOMAL 16S
Subjects
Details
- ISSN :
- 12019712
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....7a75ec91b3edead9d30b4b6e1ed77d2b