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Effects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: A double-blind randomized controlled clinical trial
- Source :
- Free Radical Biology and Medicine, Free Radical Biology and Medicine, Elsevier, 2015, 81, pp.158-169. ⟨10.1016/j.freeradbiomed.2014.09.014⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. As growing evidence suggests that oxidative stress may contribute to FSHD pathology, antioxidants that might modulate or delay oxidative insults could help in maintaining FSHD muscle function. Our primary objective was to test whether oral administration of vitamin C, vitamin E, zinc gluconate, and selenomethionine could improve the physical performance of patients with FSHD. Adult patients with FSHD (n=53) were enrolled at Montpellier University Hospital (France) in a randomized, double-blind, placebo-controlled pilot clinical trial. Patients were randomly assigned to receive 500 mg vitamin C, 400mg vitamin E, 25mg zinc gluconate and 200 μg selenomethionine (n=26), or matching placebo (n=27) once a day for 17 weeks. Primary outcomes were changes in the two-minute walking test (2-MWT), maximal voluntary contraction, and endurance limit time of the dominant and nondominant quadriceps (MVCQD, MVCQND, TlimQD, and TlimQND, respectively) after 17 weeks of treatment. Secondary outcomes were changes in the antioxidant status and oxidative stress markers. Although 2-MWT, MVCQ, and TlimQ were all significantly improved in the supplemented group at the end of the treatment compared to baseline, only MVCQ and TlimQ variations were significantly different between groups (MVCQD: P=0.011; MVCQND: P=0.004; TlimQD: P=0.028; TlimQND: P=0.011). Similarly, the vitamin C (P
- Subjects :
- Male
Antioxidant
medicine.medical_treatment
Administration, Oral
Pilot Projects
Ascorbic Acid
Walking
medicine.disease_cause
Biochemistry
Antioxidants
Physical performance
0302 clinical medicine
Vitamin E
Facioscapulohumeral muscular dystrophy
Selenomethionine
Gait
ComputingMilieux_MISCELLANEOUS
0303 health sciences
Chemistry
Autosomal dominant trait
Middle Aged
Muscular Dystrophy, Facioscapulohumeral
3. Good health
Radical oxygen species
Female
Muscle Contraction
Adult
medicine.medical_specialty
Gluconates
Facioscapulohumeral muscular dystrophy (FSHD)
03 medical and health sciences
Atrophy
Double-Blind Method
Physiology (medical)
Internal medicine
medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Humans
Muscle, Skeletal
030304 developmental biology
Vitamin C
medicine.disease
Ascorbic acid
Endocrinology
Oxidative stress
Dietary Supplements
Physical Endurance
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 08915849
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine, Free Radical Biology and Medicine, Elsevier, 2015, 81, pp.158-169. ⟨10.1016/j.freeradbiomed.2014.09.014⟩
- Accession number :
- edsair.doi.dedup.....7aa9004e01a4f5b55bed3c84a0a049c7