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The genome sequence of the filamentous fungus Neurospora crassa

Authors :
Matthew G. Endrizzi
Li-Jun Ma
Ian T. Paulsen
Gregory O. Kothe
David B. Jaffe
David E. A. Catcheside
Edward M. Marcotte
Jonathan Butler
Giuseppe Macino
Matthew S. Sachs
David D. Perkins
Jerome Naylor
Oded Yarden
Nick O. Read
Shunguang Wang
Sarah E. Calvo
Reinhard Engels
J. Andrew Berglund
Nicole Stange-Thomann
Robert L. Metzenberg
Stephan Seiler
Scott Kroken
Seth Purcell
Dmitrij Frishman
Ulrich Schulte
Bruce W. Birren
Dayong Qui
Manolis Kamvysselis
Edward L. Braun
Gregory Jedd
Rodolfo Aramayo
Mary Anne Nelson
Sante Gnerre
Carlo Cogoni
Deborah Bell-Pedersen
Rodger B. Voelker
Chad Nusbaum
David Greenberg
Robert J. Pratt
Gertrud Mannhaupt
Bushra Rehman
Carolyn G. Rasmussen
Colin P.C. DeSouza
Michael Plamann
Weixi Li
Evan Mauceli
Daniel J. Ebbole
Katherine A. Borkovich
William Fitzhugh
Svetlana Krystofova
Peter Ianakiev
Claude P. Selitrennikoff
Stephen A. Osmani
Marc J. Orbach
Alice Roy
Jay C. Dunlap
Donald O. Natvig
Robert Barrett
Stephen Rudd
Louise Glass
James E. Galagan
Cord Bielke
Karen Foley
Alan Radford
John A. Kinsey
Michael Freitag
Chuck Staben
Lisa A. Alex
Alex Zelter
Cydney B. Nielsen
Margaret Werner-Washburne
Serge Smirnov
Timothy Elkins
Michael Kamal
Werner Mewes
Eric S. Lander
Eric U. Selker
Source :
Nature. 422:859-868
Publication Year :
2003
Publisher :
Springer Science and Business Media LLC, 2003.

Abstract

Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes—more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca21 signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.

Details

ISSN :
14764687 and 00280836
Volume :
422
Database :
OpenAIRE
Journal :
Nature
Accession number :
edsair.doi.dedup.....7ab924a6bdb515460badfe13315ccc58
Full Text :
https://doi.org/10.1038/nature01554