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The genome sequence of the filamentous fungus Neurospora crassa
- Source :
- Nature. 422:859-868
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes—more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca21 signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
- Subjects :
- Genome evolution
Genes, Fungal
Receptors, Cell Surface
Biology
Genome
Neurospora crassa
Evolution, Molecular
Multienzyme Complexes
Gene Duplication
Gene density
Calcium Signaling
Genome size
Plant Diseases
Repetitive Sequences, Nucleic Acid
Genetics
Multidisciplinary
fungi
Sequence Analysis, DNA
Genome project
DNA Methylation
biology.organism_classification
Heterotrimeric GTP-Binding Proteins
Mutagenesis
RNA, Ribosomal
Multigene Family
Schizosaccharomyces pombe
RNA Interference
Minimal genome
Diterpenes
Genome, Fungal
Signal Transduction
Subjects
Details
- ISSN :
- 14764687 and 00280836
- Volume :
- 422
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....7ab924a6bdb515460badfe13315ccc58
- Full Text :
- https://doi.org/10.1038/nature01554