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Prognostic value of copeptin in patients with acute coronary syndrome: A systematic review and meta-analysis

Authors :
Guangda He
Siming Wang
Jiapeng Lu
Yanping Wang
Source :
PLoS ONE, PLoS ONE, Vol 15, Iss 8, p e0238288 (2020)
Publication Year :
2020
Publisher :
Public Library of Science, 2020.

Abstract

BackgroundThe aim of this study was to evaluate the value of copeptin in predicting mortality including both short-term and long-term mortality in patients with acute coronary syndrome (ACS).MethodsPotential studies were searched and selected through PubMed, Embase and Cochrane databases up to December 2019. The predictive performance was evaluated by the pooled sensitivity and specificity, and summary receiver operating characteristic curves. Cochran's Q test and I2 index were used to assess between-study heterogeneity, and Deek's test and funnel plots were used to assess publication bias.ResultsTotal six studies comprising 2269 patients were included in this meta-analysis. The area under the receiver operating characteristic curve of copeptin in predicting mortality in patients with ACS was 0.73 (95% CI: 0.69-0.77). The pooled sensitivity and specificity of copeptin were 0.77 (95% CI: 0.59-0.89) and 0.60 (95% CI: 0.47-0.71), respectively. Significant between-study heterogeneity was identified in both sensitivity (P = 0.01; I2 = 69.76%) and specificity (PConclusionsCopeptin has acceptable prognostic value for mortality in patients with ACS. Further studies based on multimarker strategy are needed to evaluate the prognostic value of copeptin for ACS in conjunction with other well-established biomarkers.

Details

Language :
English
ISSN :
19326203
Volume :
15
Issue :
8
Database :
OpenAIRE
Journal :
PLoS ONE
Accession number :
edsair.doi.dedup.....7afe38a831917d495cd29623dab55d1a