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Prognostic value of copeptin in patients with acute coronary syndrome: A systematic review and meta-analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 15, Iss 8, p e0238288 (2020)
- Publication Year :
- 2020
- Publisher :
- Public Library of Science, 2020.
-
Abstract
- BackgroundThe aim of this study was to evaluate the value of copeptin in predicting mortality including both short-term and long-term mortality in patients with acute coronary syndrome (ACS).MethodsPotential studies were searched and selected through PubMed, Embase and Cochrane databases up to December 2019. The predictive performance was evaluated by the pooled sensitivity and specificity, and summary receiver operating characteristic curves. Cochran's Q test and I2 index were used to assess between-study heterogeneity, and Deek's test and funnel plots were used to assess publication bias.ResultsTotal six studies comprising 2269 patients were included in this meta-analysis. The area under the receiver operating characteristic curve of copeptin in predicting mortality in patients with ACS was 0.73 (95% CI: 0.69-0.77). The pooled sensitivity and specificity of copeptin were 0.77 (95% CI: 0.59-0.89) and 0.60 (95% CI: 0.47-0.71), respectively. Significant between-study heterogeneity was identified in both sensitivity (P = 0.01; I2 = 69.76%) and specificity (PConclusionsCopeptin has acceptable prognostic value for mortality in patients with ACS. Further studies based on multimarker strategy are needed to evaluate the prognostic value of copeptin for ACS in conjunction with other well-established biomarkers.
- Subjects :
- Publication Ethics
030204 cardiovascular system & hematology
Cardiovascular Medicine
Biochemistry
Vascular Medicine
Cohort Studies
0302 clinical medicine
Mathematical and Statistical Techniques
Medical Conditions
Medicine and Health Sciences
Coronary Heart Disease
030212 general & internal medicine
Research Integrity
Multidisciplinary
Statistics
Glycopeptides
Metaanalysis
Prognosis
Research Design
Cardiovascular Diseases
Meta-analysis
Physical Sciences
Medicine
Research Article
Funnel plot
Acute coronary syndrome
medicine.medical_specialty
Drug Research and Development
Science Policy
Science
Cardiology
Research and Analysis Methods
03 medical and health sciences
Copeptin
Diagnostic Medicine
Internal medicine
medicine
Humans
In patient
Clinical Trials
Statistical Methods
Acute Coronary Syndrome
Pharmacology
Receiver operating characteristic
business.industry
Biology and Life Sciences
Publication bias
Cardiovascular Disease Risk
medicine.disease
Randomized Controlled Trials
Clinical Medicine
business
Mathematics
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....7afe38a831917d495cd29623dab55d1a