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Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors: dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment
- Source :
- Nanoscale, Marino, A, Camponovo, A, Degl'Innocenti, A, Bartolucci, M, Tapeinos, C, Martinelli, C, De Pasquale, D, Santoro, F, Mollo, V, Arai, S, Suzuki, M, Harada, Y, Petretto, A & Ciofani, G 2019, ' Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors : Dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment ', Nanoscale, vol. 11, no. 44, pp. 21227-21248 . https://doi.org/10.1039/c9nr07976a
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- Aiming at finding new solutions for fighting glioblastoma multiforme, one of the most aggressive and lethal human cancer, here an in vitro validation of multifunctional nanovectors for drug delivery and hyperthermia therapy is proposed. Hybrid magnetic lipid nanoparticles have been fully characterized and tested on a multi-cellular complex model resembling the tumor microenvironment. Investigations of cancer therapy based on a physical approach (namely hyperthermia) and on a pharmaceutical approach (by exploiting the chemotherapeutic drug temozolomide) have been extensively carried out, by evaluating its antiproliferative and pro-apoptotic effects on 3D models of glioblastoma multiforme. A systematic study of transcytosis and endocytosis mechanisms has been moreover performed with multiple complimentary investigations, besides a detailed description of local temperature increments following hyperthermia application. Finally, an in-depth proteomic analysis corroborated the obtained findings, which can be summarized in the preparation of a versatile, multifunctional, and effective nanoplatform able to overcome the blood-brain barrier and to induce powerful anti-cancer effects on in vitro complex models.
- Subjects :
- Hyperthermia
medicine.medical_treatment
Cell Line, Tumor
Glioblastoma
Humans
Tumor Microenvironment
Drug Delivery Systems
Hyperthermia, Induced
Magnetite Nanoparticles
Models, Biological
Temozolomide
02 engineering and technology
010402 general chemistry
01 natural sciences
Article
Cell Line
Models
medicine
General Materials Science
Chemotherapy
Tumor microenvironment
Tumor
Chemistry
Induced
Hyperthermia Treatment
Biological
021001 nanoscience & nanotechnology
medicine.disease
Hyperthermia therapy
3. Good health
0104 chemical sciences
Transcytosis
Drug delivery
Cancer research
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 20403372 and 20403364
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....7b1ae245adfac21987dbc44fcf00f95b