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Pre‐eclampsia‐like syndrome induced by severe COVID‐19: a prospective observational study
- Source :
- Bjog, BJOG: An International Journal of Obstetrics & Gynaecology
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Objectives To investigate the incidence of clinical, ultrasonographic and biochemical findings related to pre-eclampsia (PE) in pregnancies with COVID-19, and to assess their accuracy to differentiate between PE and the PE-like features associated with COVID-19. Design A prospective, observational study. Setting Tertiary referral hospital. Participants Singleton pregnancies with COVID-19 at >20+0 weeks. Methods Forty-two consecutive pregnancies were recruited and classified into two groups: severe and non-severe COVID-19, according to the occurrence of severe pneumonia. Uterine artery pulsatility index (UtAPI) and angiogenic factors (soluble fms-like tyrosine kinase-1/placental growth factor [sFlt-1/PlGF]) were assessed in women with suspected PE. Main outcome measures Incidence of signs and symptoms related to PE, such as hypertension, proteinuria, thrombocytopenia, elevated liver enzymes, abnormal UtAPI and increased sFlt-1/PlGF. Results Thirty-four cases were classified as non-severe and 8 as severe COVID-19. Five (11.9%) women presented signs and symptoms of PE, all five being among the severe COVID-19 cases (62.5%). However, abnormal sFlt-1/PlGF and UtAPI could only be demonstrated in one case. One case remained pregnant after recovery from severe pneumonia and had a spontaneous resolution of the PE-like syndrome. Conclusions Pregnant women with severe COVID-19 can develop a PE-like syndrome that might be distinguished from actual PE by sFlt-1/PlGF, LDH and UtAPI assessment. Healthcare providers should be aware of its existence and monitor pregnancies with suspected pre-eclampsia with caution. Tweetable abstract This study shows that a pre-eclampsia-like syndrome could be present in some pregnancies with severe COVID-19.
- Subjects :
- sFlt‐1
medicine.medical_specialty
angiogenic factors
Pneumonia, Viral
macromolecular substances
Tertiary referral hospital
SARS‐CoV‐2
Preeclampsia
preeclampsia
preeclampsia‐like syndrome
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Pre-Eclampsia
COVID‐19
Pregnancy
medicine.artery
Obstetrics and Gynaecology
Severity of illness
medicine
Humans
Main Research Article
Prospective Studies
Pregnancy Complications, Infectious
Uterine artery
Pandemics
SARS
030219 obstetrics & reproductive medicine
Eclampsia
Proteinuria
SARS-CoV-2
business.industry
Obstetrics
Incidence (epidemiology)
COVID-19
Obstetrics and Gynecology
Main Research Articles
medicine.disease
PlGF
Female
medicine.symptom
Coronavirus Infections
business
Subjects
Details
- ISSN :
- 14710528 and 14700328
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- BJOG: An International Journal of Obstetrics & Gynaecology
- Accession number :
- edsair.doi.dedup.....7b1e7bfc6aae77888740b9c85c4e55cf