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Identification and function of MicroRNAs encoded by herpesviruses

Authors :
Shou-Jiang Gao
Lin-ding Wang
Zhiqiang Bai
Xiufen Lei
Source :
Virologica Sinica. 23:459-472
Publication Year :
2008
Publisher :
Elsevier BV, 2008.

Abstract

MicroRNAs (miRNAs) play important roles in eukaryotes, plants and some viruses. It is increasingly clear that miRNAs-encoded by viruses can affect the viral life cycle and host physiology. Viral miRNAs could repress the innate and adaptive host immunity, modulate cellular signaling pathways, and regulate the expression of cellular and viral genes. These functions facilitate viral acute and persistent infections, and have profound effects on the host cell survival and disease progression. Here, we discuss the miRNAs encoded by herpesviruses, and their regulatory roles involved in virus-host interactions.

Details

ISSN :
1995820X and 16740769
Volume :
23
Database :
OpenAIRE
Journal :
Virologica Sinica
Accession number :
edsair.doi.dedup.....7b2a4fbb154eb8215983f57501be4d41