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Damage to the right dorsal anterior cingulate cortex induces panic disorder
- Source :
- Journal of affective disorders. 133(3)
- Publication Year :
- 2011
-
Abstract
- Brain imaging studies suggest that panic disorder (PD) is mediated by several brain regions, including the anterior cingulate cortex (ACC). In the present report we describe a patient who experienced a panic attack during awake surgery (case 1) and another patient who developed PD after surgery and radiotherapy (case 2). In case 1, the patient experienced repeated panic attacks when the tumor at the upper border of right dorsal ACC was removed during awake surgery. In case 2, the patient developed PD at six months after surgery and Cyberknife radiotherapy. MRI examination revealed that the dorsal ACC size was reduced at six months after surgery and that the dorsal ACC was absent at two years after surgery, possibly due to radiotherapy-induced damage by radiotherapy. Profile of mood states (POMS) testing characterized the presence of tension-anxiety as the common abnormal symptom in cases 1 and 2. In conclusion, these results suggest that damage to the right dorsal ACC can induce PD and that this structure likely plays a pathophysiologic role in PD.
- Subjects :
- Adult
Brain tumor
Anxiety
Profile of mood states
behavioral disciplines and activities
Brain mapping
Gyrus Cinguli
Neuroimaging
medicine
Humans
Radiation Injuries
Anterior cingulate cortex
Brain Mapping
medicine.diagnostic_test
Brain Neoplasms
Panic disorder
Panic
Brain
Magnetic resonance imaging
Middle Aged
medicine.disease
Anxiety Disorders
Magnetic Resonance Imaging
Psychiatry and Mental health
Clinical Psychology
medicine.anatomical_structure
Anesthesia
Panic Disorder
Female
medicine.symptom
Psychology
Subjects
Details
- ISSN :
- 15732517
- Volume :
- 133
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of affective disorders
- Accession number :
- edsair.doi.dedup.....7b5606a49b8af13b1111ce98d7faeeac