Back to Search
Start Over
Investigating the Effect of Thermal Stress on Nerve Action Potential Using the Soliton Model
- Source :
- Ultrasound in Medicine & Biology. 41:1668-1680
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- The thermal mechanism of acoustic modulation of the reversible electrical activities of peripheral nerves is investigated using the soliton model, and a numerical solution is presented for its non-homogenous version. Our results indicate that heating a small segment of the nerve will increase the action potential conduction velocity and decrease its amplitude. Moreover, cooling the nerve will have the reverse effects, and cooling to temperatures below the nerve melting point can reflect back a significant portion of the action potentials. These results are consistent with the theory of the soliton model, as well as with the experimental findings. Although there exists a discrepancy between the results of the soliton model and experimental pulse amplitude data, from the free energy point of view, the experiments are compatible with Heimburg and Jackson theory. We conclude that the presented model accompanied by the free energy view is capable of simulating the effects of thermal energy on nerve function. One potential application of the developed theoretical model will be investigation of the reversible and irreversible effects of thermal energy induced by various energy modalities, including therapeutic ultrasound, on nerve function.
- Subjects :
- Hot Temperature
Materials science
Acoustics and Ultrasonics
Action potential
Neural Conduction
Biophysics
Action Potentials
Models, Biological
Nerve conduction velocity
symbols.namesake
Optics
Thermal
Computer Simulation
Radiology, Nuclear Medicine and imaging
Peripheral Nerves
Radiological and Ultrasound Technology
business.industry
Mechanics
Gibbs free energy
Amplitude
Ultrasonic Waves
symbols
Soliton
business
Energy (signal processing)
Thermal energy
Subjects
Details
- ISSN :
- 03015629
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Ultrasound in Medicine & Biology
- Accession number :
- edsair.doi.dedup.....7b5d59ae6e0f881c1129ae222ccfb843