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Associations of IL-12, IL12R polymorphisms and serum IL-12 levels with high-risk human papillomavirus susceptibility in rural women from Luohe, Henan, China
- Source :
- Medicine
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Background: Interleukin 12 (IL-12) and interleukin 12 receptor (IL12R), key inflammatory cytokines in the immune system, participate in bridging the innate immunity and adaptive immunity. No previous work has reported the role of IL-12 and IL12R in high-risk human papillomavirus (hrHPV) susceptibility. The purpose of this study was to investigate the association of IL-12, IL12R polymorphisms, and serum IL-12 levels with hrHPV susceptibility in rural women from Luohe, Henan, China. Methods: Two hundred sixty cases with hrHPV infection and 260 healthy controls were selected. Enzyme-linked immunosorbent assays were used to detect the serum IL-12 levels, and the polymorphisms of IL12B rs3212227, IL12RB1 rs393548, and IL12RB1 rs436857 were determined using DNA sequencing. Results: The serum IL-12 levels were significantly lower in cases with hrHPV infection compared with those in healthy controls (P .05). Furthermore, with respect to the IL12 rs3212227 polymorphism with serum IL-12 levels, although serum IL-12 levels were lower in cases than in controls, we did not find any differences between serum IL-12 levels and genotypes in cases(P > .05). Conclusions: Our data demonstrates that low serum IL-12 levels may be associated with hrHPV susceptibility but are not associated with IL-12 gene polymorphisms; furthermore, IL-12 and IL12R gene polymorphisms may not contribute susceptibility to hrHPV in rural women from Luohe, Henan, China.
- Subjects :
- Adult
Rural Population
China
Enzyme-Linked Immunosorbent Assay
Polymorphism, Single Nucleotide
susceptibility
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
Immune system
Asian People
Genotype
Humans
Medicine
Genetic Predisposition to Disease
030212 general & internal medicine
Interleukin 12 receptor, beta 1 subunit
Aged
Interleukin-12 Subunit p40
business.industry
Papillomavirus Infections
Receptors, Interleukin-12
Case-control study
Clinical Trial/Experimental Study
General Medicine
Middle Aged
Acquired immune system
IL12R
IL-12
Case-Control Studies
030220 oncology & carcinogenesis
Interleukin-12 receptor
Immunology
Interleukin 12
Female
polymorphisms
business
high-risk human papillomavirus
Research Article
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....7b5f8eee216332558cffad1c7cb150af
- Full Text :
- https://doi.org/10.1097/md.0000000000016991